Neutrophil membranes coated, antibiotic agent loaded nanoparticles targeting to the lung inflammation

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 188; p. 110755
• Main Authors: Wang, Kaiyu, Lei, Yiteng, Xia, Donglin, Xu, Peipei, Zhu, Tao, Jiang, Zhongying, Ma, Yuqiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2020
• Subjects: adverse effects; antibiotics; bacteria; biocompatibility; cell membranes; cytokines; cytotoxicity; death; drug delivery systems; drugs; in vivo studies; Inflammation; lungs; mice; nanomedicine; Nanoparticles; neoplasms; Neutrophil membrane; neutrophils; pathogens; patients; Pneumonia; risk reduction; Sparfloxacin; Nanoparticles; Neutrophil membrane; Pneumonia; Inflammation; Sparfloxacin

[Display omitted] •Antibiotic drug loaded nanoparticles coated with neutrophil membranes (NM-NP-SPX) were developed.•NM-NP-SPX had the abilities of controlled-release and biocompatibility.•NM-NP-SPX could precisely target to the sites of inflammation.•NM-NP-SPX could cure pneumonia effectively witho...