Thiophenecarboxylate Suppressor of Cyclic Nucleotides Discovered in a Small-Molecule Screen Blocks Toxin-Induced Intestinal Fluid Secretion - Tradtrantip, Lukmanee; Yangthara, Buranee; Padmawar, Prashant; Morrison, Christopher; Verkman, A.S. (Molecular pharmacology, 2009)
Keywords: Animals; Cell Line; Cells, Cultured; CHO Cells; Cholera Toxin - antagonists & inhibitors; Cricetinae; Cricetulus; Cyclic AMP - metabolism; Cyclic GMP - metabolism; Cystic Fibrosis Transmembrane Conductance Regulator - metabolism; Disease Models, Animal; Dogs; Inorganic Chemicals - chemical synthesis; Inorganic Chemicals - chemistry; Inorganic Chemicals - metabolism; Intestinal Secretions - metabolism; Kidney - cytology; Mice; Mice, Inbred Strains; Molecular Structure; Nucleotides, Cyclic - analysis; Nucleotides, Cyclic - antagonists & inhibitors; Polycystic Kidney Diseases - drug therapy; Rats; Rats, Inbred F344; Stereoisomerism; Structure-Activity Relationship; Thyroid Gland - cytology; Thyroid Gland - metabolism; Transfection