Methodological comparison of the allele refractory mutation system and direct sequencing for detecting EGFR mutations in NSCLC, and the association of EGFR mutations with patient characteristics

• Published in: Oncology letters Vol. 16; no. 1; pp. 1087 - 1094
• Main Authors: Wu, Minmin, Pan, Xiaodong, Xu, Yaya, Wu, Siying, Wu, Xiuling, Chen, Bicheng
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.07.2018; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Age; Biopsy; Care and treatment; Comparative analysis; Deoxyribonucleic acid; Development and progression; DNA; Epidermal growth factor; Gefitinib; Genes; Genetic aspects; Kinases; Lung cancer; Lung cancer, Non-small cell; Medical prognosis; Methods; Mutation; Oncology; Patient outcomes; Squamous cell carcinoma; Beijing China; China; non-small cell lung cancer; mutation rate; amplification refractory mutation system; direct sequencing method; epidermal growth factor receptor

Gefitinib is effective for patients with non-small cell lung cancer (NSCLC) with a mutation in the epidermal growth factor receptor (EGFR) gene, which makes the detection of EGFR mutations a critical step prior to determining a treatment schedule. Therefore, the present study determined the EGFR mut...