Antihelminthic niclosamide modulates dendritic cells activation and function

• Published in: Cellular immunology Vol. 288; no. 1-2; pp. 15 - 23
• Main Authors: Wu, Chieh-Shan, Li, Yi-Rong, Chen, Jeremy J.W., Chen, Ying-Che, Chu, Chiang-Liang, Pan, I-Hong, Wu, Yu-Shan, Lin, Chi-Chen
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2014
• Subjects: Animals; Anthelmintics - immunology; Anthelmintics - pharmacology; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; Bone Marrow Cells - immunology; Cell Proliferation - drug effects; Cells, Cultured; Coculture Techniques; Contact hypersensitivity (CHS); Cytokine; Dendritic cells; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dinitrofluorobenzene - administration & dosage; Dinitrofluorobenzene - immunology; Female; Gene Expression Regulation; Hypersensitivity - immunology; Hypersensitivity - prevention & control; Immunization; Immunomodulation - drug effects; Injections, Intravenous; Lipopolysaccharides - pharmacology; Lymphocyte Activation - drug effects; MAP Kinase Kinase 4 - genetics; MAP Kinase Kinase 4 - immunology; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases - genetics; Mitogen-Activated Protein Kinase Kinases - immunology; NF-kappa B - genetics; NF-kappa B - immunology; Niclosamide; Niclosamide - immunology; Niclosamide - pharmacology; Signal Transduction; T cell proliferation; T-Lymphocytes - cytology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Niclosamide; Contact hypersensitivity (CHS); T cell proliferation; Dendritic cells; Cytokine

•Effect of niclosamide on the activation of LPS-stimulated BMDCs was investigated.•Niclosamide decreased ability to stimulate antigen specific T cell proliferation.•Niclosamide attenuated hapten induced contact hypersensitivity (CHS) in vivo.•Blocking the MAPK and NF-κB contribute to the inhibitory...