m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

• Published in: Molecular cancer Vol. 19; no. 1; pp. 1 - 15
• Main Authors: Tang, Bo, Yang, Yihua, Kang, Min, Wang, Yunshan, Wang, Yan, Bi, Yin, He, Songqing, Shimamoto, Fumio
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 06.01.2020; BioMed Central; BMC
• Subjects: Adenocarcinoma; ALKBH5; Analysis; Breast cancer; Cancer therapies; Cancer treatment; Cell growth; Cell migration; Cell proliferation; Chemo-resistance; Chemotherapy; Epigenetic inheritance; Epigenetics; Gemcitabine; Gene expression; Gene regulation; Genes; Genetic regulation; Genetic research; Immunoglobulins; m6A methylation; Mediation; Medical prognosis; Metastasis; Methylation; Methyltransferases; N6-methyladenosine; Pancreatic cancer; Prognosis; Proteins; RNA; RNA modification; Sensitizing; Statistical analysis; Tumorigenesis; Tumors; Western blotting; WIF-1; Wnt; Wnt protein; Xenografts; United States > US; Grand Island New York

Abstract Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor diagnosis and prognosis, and chemo-resistance remains a major challenge. The dynamic and reversible N 6 -methyladenosine (m 6 A) RNA modification has emerged as a new layer of epigenetic gene regulati...