Systematic review: Pharmacological treatment of tic disorders – Efficacy of antipsychotic and alpha-2 adrenergic agonist agents

• Published in: Neuroscience and biobehavioral reviews Vol. 37; no. 6; pp. 1162 - 1171
• Main Authors: Weisman, Hannah, Qureshi, Imraan A., Leckman, James F., Scahill, Lawrence, Bloch, Michael H.
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Adrenergic alpha-Agonists - therapeutic use; Age Factors; Animals; Antidiarrheals - therapeutic use; Attention Deficit Disorder with Hyperactivity - drug therapy; Attention Deficit Disorder with Hyperactivity - etiology; Clinical Trials as Topic; Humans; Meta-Analysis as Topic; PubMed - statistics & numerical data; Tic Disorders - complications; Tic Disorders - drug therapy

We conducted a meta-analysis of randomized, placebo-controlled trials to determine the efficacy of antipsychotic and alpha-2 agonists in the treatment of chronic tic disorders and examine moderators of treatment effect. Meta-analysis demonstrated a significant benefit of antipsychotics compared to p...