Epitope mapping of a monoclonal antibody specific for human herpesvirus 6 variant A immediate-early 2 protein

• Published in: Journal of clinical virology Vol. 38; no. 4; pp. 286 - 291
• Main Authors: Tomoiu, Andru, Flamand, Louis
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2007; Elsevier Science
• Subjects: Allergy and Immunology; Antibodies, Monoclonal - immunology; Antibodies, Viral - immunology; Biological and medical sciences; Cell Line; Epitope Mapping; Fundamental and applied biological sciences. Psychology; Herpesvirus 6, Human - immunology; Human herpesvirus 6; Human viral diseases; Humans; IE2 protein; Immediate-Early Proteins - genetics; Immediate-Early Proteins - immunology; Infectious Disease; Infectious diseases; Medical sciences; Microbiology; Miscellaneous; Oligopeptides - chemical synthesis; Oligopeptides - immunology; P6H8 monoclonal antibody; Roseolovirus Infections - diagnosis; Roseolovirus Infections - virology; Sensitivity and Specificity; Sequence Deletion; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Viral diseases; Virology; human herpesvirus 6; immediate-early; IE2 protein; P6H8 monoclonal antibody; HHV-6; IE; monoclonal antibody; mAb; Human herpesvirus 6; Antigenic determinant; Microbiology; Monoclonal antibody; Protein; Virology

Abstract Background Human herpesvirus 6 (HHV-6) variants A and B are distinct viruses that differ in their biological properties and association to disease. Diagnostic tools able to discriminate between these two variants and between active or latent HHV-6 infection are much needed. In our effort to...