Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia

• Published in: The FASEB journal Vol. 31; no. 8; p. 3649
• Main Authors: Michelucci, Antonio, Paolini, Cecilia, Boncompagni, Simona, Canato, Marta, Reggiani, Carlo, Protasi, Feliciano
• Format: Journal Article
• Language: English
• Published: United States 01.08.2017
• Subjects: Animals; Caffeine - pharmacology; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - metabolism; Electric Stimulation; Gene Expression Regulation - physiology; Genetic Predisposition to Disease; Malignant Hyperthermia - genetics; Malignant Hyperthermia - pathology; Mice; Mice, Knockout; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiology; Physical Conditioning, Animal; Physical Exertion; Rhabdomyolysis; Ryanodine Receptor Calcium Release Channel - genetics; Ryanodine Receptor Calcium Release Channel - metabolism; calsequestrin-1; ryanodine receptor; skeletal muscle; excitation-contraction coupling; sarcoplasmic reticulum

In humans, hyperthermic episodes can be triggered by halogenated anesthetics [malignant hyperthermia (MH) susceptibility] and by high temperature [environmental heat stroke (HS)]. Correlation between MH susceptibility and HS is supported by extensive work in mouse models that carry a mutation in rya...