Association of Nrf2 expression and mutation with Weiss and Helsinki scores in adrenocortical carcinoma

• Published in: Cancer science Vol. 113; no. 7; pp. 2368 - 2377
• Main Authors: Kamai, Takao, Murakami, Satoshi, Arai, Kyoko, Ishida, Kazuyuki, Kijima, Toshiki
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2022; John Wiley and Sons Inc
• Subjects: [18F]fluorodeoxy‐glucose positron emission tomography (18F‐FDG‐PET); Adenoma; adrenocortical carcinoma; Antioxidants; Cancer; Glucose; Labeling; Magnetic resonance imaging; Medical prognosis; Metabolism; Metastasis; Morphology; Mutants; Mutation; NRF2 protein; nuclear factor E2–related factor 2 (Nrf2); Original; ORIGINAL ARTICLES; Oxidative stress; p53; Patients; Point mutation; Positron emission tomography; Proteins; Reactive oxygen species; Surgery; Therapeutic targets; Tomography; Tumors; Weiss and Helsinki scores; adrenocortical carcinoma; [18F]fluorodeoxy-glucose positron emission tomography (18F-FDG-PET); Weiss and Helsinki scores; nuclear factor E2-related factor 2 (Nrf2); p53

Adrenocortical carcinoma (ACC) is a rare malignant tumor. Genetic abnormalities that may represent therapeutic targets and prognostic factors in ACC remain unclear. Besides being one of the main cellular defense mechanisms that regulates antioxidant pathways for detoxifying reactive oxygen species (...