Dopaminergic genes modulate response inhibition in alcohol abusing adults
ABSTRACT Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mech...
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| Published in | Addiction biology Vol. 17; no. 6; pp. 1046 - 1056 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.11.2012
John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | ABSTRACT
Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster‐corrected P < 0.05, z = 1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster‐corrected P < 0.05, z = 1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self‐monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence. |
|---|---|
| AbstractList | ABSTRACT
Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2
rs1799732
and
DRD4 VNTR
, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the
DRD4 VNTR
during successful inhibition in the inferior frontal gyrus (IFG) (cluster‐corrected
P
< 0.05, z = 1.9). Similarly, DRD2
rs1799732
groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster‐corrected
P
< 0.05, z = 1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self‐monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence. ABSTRACT Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster-corrected P<0.05, z=1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster-corrected P<0.05, z=1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self-monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence. Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster-corrected P<0.05, z=1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster-corrected P<0.05, z=1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self-monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence. Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster-corrected P < 0.05, z = 1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster-corrected P < 0.05, z = 1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self-monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence. [PUBLICATION ABSTRACT] ABSTRACT Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster‐corrected P < 0.05, z = 1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster‐corrected P < 0.05, z = 1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self‐monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence. Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been implicated not only for risk for AUD but also for impulsivity based on behavioral studies, we set out to examine the underlying neural mechanisms associated with these effects. We collected functional magnetic resonance imaging images on 53 heavy drinking but otherwise healthy adults while performing the Go/NoGo task. We predicted that genetic variants previously reported in the literature to be associated with substance abuse, specifically the DRD2 rs1799732 and DRD4 VNTR, will modulate neural processes underlying response inhibition. Our results showed differential neural response for the DRD4 VNTR during successful inhibition in the inferior frontal gyrus (IFG) (cluster-corrected P<0.05, z=1.9). Similarly, DRD2 rs1799732 groups were significantly different in the precuneus and cingulate gyrus during successful response inhibition (cluster-corrected P<0.05, z=1.9). These findings provide further evidence for the role of DAergic genes in modulating neural response in areas that underlie response inhibition and self-monitoring processes. Variants within these genes appear to influence processes related to impulsive behavior, which may increase one's risk for alcohol abuse and dependence. |
| Author | Claus, Eric D. Morgan, Marilee Forester, Glen R. Filbey, Francesca M. Hutchison, Kent |
| Author_xml | – sequence: 1 givenname: Francesca M. surname: Filbey fullname: Filbey, Francesca M. email: francesca.filbey@utdallas.edu organization: Center for BrainHealth, School of Behavioral and Brain Sciences, University of Texas, Dallas, Dallas, TX, USA – sequence: 2 givenname: Eric D. surname: Claus fullname: Claus, Eric D. organization: The Mind Research Network, Albuquerque, NM, USA – sequence: 3 givenname: Marilee surname: Morgan fullname: Morgan, Marilee organization: The Mind Research Network, Albuquerque, NM, USA – sequence: 4 givenname: Glen R. surname: Forester fullname: Forester, Glen R. organization: Department of Psychology, University of New Mexico, Albuquerque, NM, USA – sequence: 5 givenname: Kent surname: Hutchison fullname: Hutchison, Kent organization: The Mind Research Network, Albuquerque, NM, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21554498$$D View this record in MEDLINE/PubMed |
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Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have... Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have been... ABSTRACT Compulsion in alcohol use disorders (AUD) has been attributed to impairment in response inhibition. Because genes that regulate dopamine (DA) have... |
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| SubjectTerms | Addiction Adult Alcohol use disorders Alcohol-Related Disorders - genetics Alcohol-Related Disorders - physiopathology Alcoholism - genetics Alcoholism - physiopathology Alleles Brain - physiopathology Computed tomography Cortex (parietal) Dopamine Dopamine D2 receptors Dopamine D4 receptors Drinking behavior Drug abuse Ethanol Female fMRI frontal gyrus Frontal Lobe - physiopathology Functional magnetic resonance imaging Functional Neuroimaging genes Genotype Go/no-go discrimination learning Go/NoGo Gyrus Cinguli - physiopathology Humans impulsive behavior Impulsive Behavior - genetics Impulsive Behavior - physiopathology Inhibition (Psychology) Magnetic Resonance Imaging Male Minisatellite Repeats Parietal Lobe - physiopathology Phenotype Polymorphism, Single Nucleotide Receptors, Dopamine D2 - genetics Receptors, Dopamine D4 - genetics response inhibition |
| Title | Dopaminergic genes modulate response inhibition in alcohol abusing adults |
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