Icariin‐induced inhibition of SIRT6/NF‐κB triggers redox mediated apoptosis and enhances anti‐tumor immunity in triple‐negative breast cancer

• Published in: Cancer science Vol. 111; no. 11; pp. 4242 - 4256
• Main Authors: Song, Linjiang, Chen, Xian, Mi, Ling, Liu, Chi, Zhu, Shaomi, Yang, Tianlin, Luo, Xiaohong, Zhang, Qinxiu, Lu, Hua, Liang, Xin
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.11.2020; John Wiley and Sons Inc
• Subjects: Animals; anti‐tumor immunity; Apoptosis; Apoptosis - drug effects; Breast cancer; Cancer therapies; Cell adhesion & migration; Cell culture; Cell growth; Cell Line, Tumor; Cell migration; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Cytotoxicity; Disease Models, Animal; Drugs; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Experiments; Female; Flavonoids - chemistry; Flavonoids - pharmacology; Flavonols; Gene Expression Profiling; Humans; icariin; Immunity; Metastases; Metastasis; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Models, Biological; Neoplasm Metastasis; Neoplasm Staging; NF-kappa B - metabolism; NF‐κB; Original; Oxidation-Reduction - drug effects; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal transduction; Sirtuins - metabolism; Transcription, Genetic; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - etiology; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; triple‐negative breast cancer; Womens health; Xenograft Model Antitumor Assays; NF-κB; icariin; triple-negative breast cancer; anti-tumor immunity; metastasis

Abnormal activation of the nuclear factor‐kappa B (NF‐κB) signaling pathway is closely implicated in triple‐negative breast cancer growth, metastasis, and tumor immune escape. In this study, the anti‐cancer effects of icariin, a natural flavonol glycoside, toward breast cancer cells and the underlyi...