Blood-based gene-expression predictors of PTSD risk and resilience among deployed marines: A pilot study

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 162B; no. 4; pp. 313 - 326
• Main Authors: Glatt, Stephen J., Tylee, Daniel S., Chandler, Sharon D., Pazol, Joel, Nievergelt, Caroline M., Woelk, Christopher H., Baker, Dewleen G., Lohr, James B., Kremen, William S., Litz, Brett T., Tsuang, Ming T.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2013; Wiley Subscription Services, Inc
• Subjects: Adult; alternative splicing; Case-Control Studies; Exons; Gene Expression Profiling; Genetic Predisposition to Disease; Genetics; Humans; Military Personnel; mRNA; peripheral blood mononuclear cells; Pilot Projects; Prospective Studies; Resilience, Psychological; RNA, Messenger - blood; Stress Disorders, Post-Traumatic - blood; Stress Disorders, Post-Traumatic - genetics; Stress Disorders, Post-Traumatic - psychology; transcriptome; trauma; Young Adult

Susceptibility to PTSD is determined by both genes and environment. Similarly, gene‐expression levels in peripheral blood are influenced by both genes and environment, and expression levels of many genes show good correspondence between peripheral blood and brain. Therefore, our objectives were to t...