Centrally mediated increased sympathetic activity is not important in the genesis of ACTH-induced hypertension in sheep

• Published in: Clinical and experimental pharmacology & physiology Vol. 16; no. 7; p. 607
• Main Authors: Spence, C D, Mathai, M, Mills, E H, Coghlan, J P, Whitworth, J A, Scoggins, B A
• Format: Journal Article
• Language: English
• Published: Australia 01.07.1989
• Subjects: Adrenocorticotropic Hormone; Animals; Blood Pressure - drug effects; Clonidine - pharmacology; Female; Heart Rate - drug effects; Hypertension - chemically induced; Hypertension - physiopathology; Injections, Intravenous; Methyldopa - pharmacology; Sheep; Sympathetic Nervous System - physiopathology; Vascular Resistance - drug effects

1. Adrenocorticotrophin (ACTH) administration to sheep produces a rapid adrenally dependent hypertension which is maximal after 3 days and associated with increased cardiac output (CO) and heart rate (HR), while calculated total peripheral resistance remains unchanged. 2. This study investigated the...