RNF20 Regulates Oocyte Meiotic Spindle Assembly by Recruiting TPM3 to Centromeres and Spindle Poles

• Published in: Advanced science Vol. 11; no. 13; pp. e2306986 - n/a
• Main Authors: Wang, Liying, Liu, Chao, Li, Li, Wei, Huafang, Wei, Wei, Zhou, Qiuxing, Chen, Yinghong, Meng, Tie‐Gang, Jiao, Renjie, Wang, Zhen‐Bo, Sun, Qing‐Yuan, Li, Wei
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.04.2024; John Wiley and Sons Inc; Wiley
• Subjects: Antibodies; Centromere; Chromosomes; Experiments; Female; Females; Humans; Infertility; Localization; Male; Meiosis; oocyte maturation; Oocytes - metabolism; Ovaries; Physiology; Proteins; Puberty; RNF20; Spindle Apparatus - metabolism; spindle assembly; Spindle Poles - metabolism; Statistical analysis; Student's t-test; TPM3; RNF20; meiosis; oocyte maturation; spindle assembly; TPM3

Previously a ring finger protein 20 (RNF20) is found to be essential for meiotic recombination and mediates H2B ubiquitination during spermatogenesis. However, its role in meiotic division is still unknown. Here, it is shown that RNF20 is localized at both centromeres and spindle poles, and it is re...