Landscape of Dysregulated Placental RNA Editing Associated With Preeclampsia

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 75; no. 6; pp. 1532 - 1541
• Main Authors: Yang, Xiaoxue, Yang, Jing, Liang, Xiaozhen, Chen, Qian, Jiang, Sijia, Liu, Haihua, Gao, Yue, Ren, Zhonglu, Shi, Yi-Wu, Li, Sheng, Yu, Yanhong, Zhong, Mei, Yang, Xinping
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.06.2020
• Subjects: Adult; Binding Sites; Cell Line; Female; Gene Expression Profiling - methods; Gene Expression Regulation; Gestational Age; Humans; Leptin - genetics; Leptin - metabolism; MicroRNAs - genetics; Placenta - metabolism; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Pre-Eclampsia - physiopathology; Pregnancy; Pregnancy Trimesters; RNA Editing - physiology; Severity of Illness Index; Up-Regulation; placenta; RNA editing; preeclampsia; hypertension; untranslated regions

Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patient...