Brain correlates of craving for online gaming under cue exposure in subjects with Internet gaming addiction and in remitted subjects
ABSTRACT This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs)....
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Published in | Addiction biology Vol. 18; no. 3; pp. 559 - 569 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.2013
John Wiley & Sons, Inc |
Subjects | |
Online Access | Get full text |
ISSN | 1355-6215 1369-1600 1369-1600 |
DOI | 10.1111/j.1369-1600.2011.00405.x |
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Abstract | ABSTRACT
This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region‐of‐interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies. |
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AbstractList | ABSTRACT
This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region‐of‐interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies. This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region‐of‐interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies. This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event-related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region-of-interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies.This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event-related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region-of-interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies. This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event-related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region-of-interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies. [PUBLICATION ABSTRACT] |
Author | Yen, Cheng-Fang Ko, Chih-Hung Liu, Gin-Chung Chen, Cheng-Sheng Chen, Chiao-Yun Yen, Ju-Yu |
Author_xml | – sequence: 1 givenname: Chih-Hung surname: Ko fullname: Ko, Chih-Hung organization: Departments of Psychiatry – sequence: 2 givenname: Gin-Chung surname: Liu fullname: Liu, Gin-Chung email: gcliu@kmu.edu.tw organization: Medical Imaging – sequence: 3 givenname: Ju-Yu surname: Yen fullname: Yen, Ju-Yu organization: Departments of Psychiatry – sequence: 4 givenname: Chiao-Yun surname: Chen fullname: Chen, Chiao-Yun organization: Medical Imaging – sequence: 5 givenname: Cheng-Fang surname: Yen fullname: Yen, Cheng-Fang organization: Departments of Psychiatry – sequence: 6 givenname: Cheng-Sheng surname: Chen fullname: Chen, Cheng-Sheng organization: Departments of Psychiatry |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22026537$$D View this record in MEDLINE/PubMed |
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References | Rudy JW (2009) Context representations, context functions, and the parahippocampal-hippocampal system. Learn Mem 16:573-585. Chen SH, Weng LC, Su YJ, Wu HM, Yang PF (2003) Development of Chinese Internet addiction scale and its psychometric study. Chin J Psychol 45:279-294. Schneider F, Habel U, Wagner M, Franke P, Salloum JB, Shah NJ. Toni I, Sulzbach C, Hönig K, Maier W, Gaebel W, Zilles K (2001) Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiatry 158:1075-1083. Cox LS, Tiffany ST, Christen AG (2001) Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tob Res 3:7-16. Ko CH, Yen JY, Yen CF, Chen CS, Chen CC (in press) The association between Internet addiction and psychiatric disorder: a review of the literature. Eur Psychiatry. Tiffany ST, Singleton E, Haertzen CA, Henningfield JE (1993) The development of a cocaine craving questionnaire. Drug Alcohol Depend 34:19-28. 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Smolka MN, Buhler M, Klein S, Zimmermann U, Mann K, Heinz A, Braus DF (2006) Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery. Psychopharmacology (Berl) 184:577-588. Chiamulera C (2005) Cue reactivity in nicotine and tobacco dependence: a "multiple-action" model of nicotine as a primary reinforcement and as an enhancer of the effects of smoking-associated stimuli. Brain Res Brain Res Rev 48:74-97. Park MS, Sohn JH, Suk JA, Kim SH, Sohn S, Sparacio R (2007) Brain substrates of craving to alcohol cues in subjects with alcohol use disorder. Alcohol Alcohol 42:417-422. Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE (2005) Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. Psychopharmacology (Berl) 183:171-180. Skinner MD, Aubin HJ (2010) Craving's place in addiction theory: contributions of the major models. Neurosci Biobehav Rev 34:606-623. Ko CH, Liu GC, Hsiao S, Yen JY, Yang MJ, Lin WC, Yen CF, Chen CS (2009a) Brain activities associated with gaming urge of online gaming addiction. J Psychiatr Res 43:739-747. McClernon FJ, Hiott FB, Liu J, Salley AN, Behm FM, Rose JE (2007) Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study. Addict Biol 12:503-512. McCormack HM, Horne DJ, Sheather S (1988) Clinical applications of visual analogue scales: a critical review. Psychol Med 18:1007-1019. Sinha R, Li CS (2007) Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications. Drug Alcohol Rev 26:25-31. Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403-1413. 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Robinson TE, Berridge KC (2008) Review The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci 363:3137-3146. Frascella J, Potenza MN, Brown LL, Childress AR (2010) Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint? Ann N Y Acad Sci 1187:294-315. Ko CH, Yen JY, Chen SH, Yang MJ, Lin HC, Yen CF (2009b) Proposed diagnostic criteria and the screening and diagnosing tool of Internet addiction in college students. Compr Psychiatry 50:378-384. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT (2000) Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 10:120-131. McClernon FJ, Kozink RV, Lutz AM, Rose JE (2009) 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. Psychopharmacology (Berl) 204:25-35. 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Yen JY, Ko CH, Yen CF, Chen CS, Chen CC (2009) The association between harmful alcohol use and Internet addiction among college students: comparison of personality. Psychiatry Clin Neurosci 63:218-224. American Psychiatric Assn (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Text Revision. Washington, DC: American Psychiatric Association. Rosenberg H (2009) Clinical and laboratory assessment of the subjective experience of drug craving. Clin Psychol Rev 29:519-534. Goudriaan AE, de Ruiter MB, van den Brink W, Oosterlaan J, Veltman DJ (2010) Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict Biol 15:491-503. Ko CH, Yen JY, Chen CC, Chen SH, Wu K, Yen CF (2006) Tridimensional personality of adolescents with internet addiction and substance use experience. Can J Psychiatry 51:887-894. Janes AC, Frederick B, Richardt S, Burbridge C, Merlo-Pich E, Renshaw PF, Evins AE, Fava M, Kaufman MJ (2009) Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence. Exp Clin Psychopharmacol 17:365-373. Pearson JM, Heilbronner SR, Barack DL, Hayden BY, Platt ML (2011) Posterior cingulate cortex: adapting behavior to a changing world. Trends Cogn Sci 15:143-151. 2010; 34 2010; 32 2009; 63 2010; 15 2011; 217 2006; 51 1988; 18 2009a; 43 2010; 18 1998 1999; 22 2011; 54 2011; 15 2002 2005; 48 2005; 26 2008; 363 2007; 12 2009b; 50 2009; 29 2009; 14 2007; 212 1993; 34 2005; 183 2005; 162 2000 2000; 12 2000; 10 2004; 15 1993; 53 2006; 184 1999; 54 2001; 3 2010; 1187 2007; 42 2006; 129 2001; 58 2009; 16 2001; 158 2009; 204 2007; 26 2003; 45 2005; 58 2009; 17 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_26_1 e_1_2_8_27_1 Talairach J (e_1_2_8_44_1) 1998 Schwartz N (e_1_2_8_39_1) 1999; 54 e_1_2_8_3_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_43_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_45_1 e_1_2_8_23_1 e_1_2_8_41_1 e_1_2_8_40_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_16_1 e_1_2_8_37_1 Ko CH (e_1_2_8_20_1) Chen SH (e_1_2_8_5_1) 2003; 45 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1 American Psychiatric Assn (e_1_2_8_2_1) 2000 Lorberbaum JP (e_1_2_8_22_1) 2004; 15 |
References_xml | – reference: Chen SH, Weng LC, Su YJ, Wu HM, Yang PF (2003) Development of Chinese Internet addiction scale and its psychometric study. Chin J Psychol 45:279-294. – reference: Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F, Baler R (2010) Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit. Bioessays 32:748-755. – reference: Ko CH, Liu GC, Hsiao S, Yen JY, Yang MJ, Lin WC, Yen CF, Chen CS (2009a) Brain activities associated with gaming urge of online gaming addiction. J Psychiatr Res 43:739-747. – reference: Schneider F, Habel U, Wagner M, Franke P, Salloum JB, Shah NJ. Toni I, Sulzbach C, Hönig K, Maier W, Gaebel W, Zilles K (2001) Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiatry 158:1075-1083. – reference: Rudy JW (2009) Context representations, context functions, and the parahippocampal-hippocampal system. Learn Mem 16:573-585. – reference: Janes AC, Frederick B, Richardt S, Burbridge C, Merlo-Pich E, Renshaw PF, Evins AE, Fava M, Kaufman MJ (2009) Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence. Exp Clin Psychopharmacol 17:365-373. – reference: McClernon FJ, Hiott FB, Liu J, Salley AN, Behm FM, Rose JE (2007) Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study. Addict Biol 12:503-512. – reference: Salmi J, Rinne T, Degerman A, Salonen O, Alho K (2007) Orienting and maintenance of spatial attention in audition and vision: multimodal and modality-specific brain activations. Brain Struct Funct 212:181-194. – reference: American Psychiatric Assn (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Text Revision. Washington, DC: American Psychiatric Association. – reference: Salzmann E, Vidyasagar TR, Creutzfeldt OD (1993) Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioural paradigms involving memory and selective attention. Behav Brain Res 53:133-149. – reference: Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403-1413. – reference: Schwartz N (1999) Self-reports: how questions shape answers. Am Psychol 54:93-105. – reference: Ko CH, Yen JY, Yen CF, Chen CS, Chen CC (in press) The association between Internet addiction and psychiatric disorder: a review of the literature. Eur Psychiatry. – reference: Risinger RC, Salmeron BJ, Ross TJ, Amen SL, Sanfilipo M, Hoffmann RG, Bloom AS, Garavan H, Stein EA (2005) Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage 26:1097-1108. – reference: Skinner MD, Aubin HJ (2010) Craving's place in addiction theory: contributions of the major models. Neurosci Biobehav Rev 34:606-623. – reference: Smolka MN, Buhler M, Klein S, Zimmermann U, Mann K, Heinz A, Braus DF (2006) Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery. Psychopharmacology (Berl) 184:577-588. – reference: Maddock RJ (1999) The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends Neurosci 22:310-316. – reference: Chiamulera C (2005) Cue reactivity in nicotine and tobacco dependence: a "multiple-action" model of nicotine as a primary reinforcement and as an enhancer of the effects of smoking-associated stimuli. Brain Res Brain Res Rev 48:74-97. – reference: Heinz A, Beck A, Grusser SM, Grace AA, Wrase J (2009) Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol 14:108-118. – reference: Ko CH, Yen JY, Chen CC, Chen SH, Wu K, Yen CF (2006) Tridimensional personality of adolescents with internet addiction and substance use experience. Can J Psychiatry 51:887-894. – reference: Rosenberg H (2009) Clinical and laboratory assessment of the subjective experience of drug craving. Clin Psychol Rev 29:519-534. – reference: Kilts CD, Schweitzer JB, Quinn CK, Gross RE, Faber TL, Muhammad F, Ely TD, Hoffman JM, Drexler KP (2001) Neural activity related to drug craving in cocaine addiction. Arch Gen Psychiatry 58:334-341. – reference: Mitchell DG (2011) The nexus between decision making and emotion regulation: a review of convergent neurocognitive substrates. Behav Brain Res 217:215-231. – reference: Ko CH, Yen JY, Chen SH, Yang MJ, Lin HC, Yen CF (2009b) Proposed diagnostic criteria and the screening and diagnosing tool of Internet addiction in college students. Compr Psychiatry 50:378-384. – reference: Tiffany ST, Singleton E, Haertzen CA, Henningfield JE (1993) The development of a cocaine craving questionnaire. Drug Alcohol Depend 34:19-28. – reference: Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129:564-583. – reference: Robinson TE, Berridge KC (2008) Review The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci 363:3137-3146. – reference: Han DH, Hwang JW, Renshaw PF (2010) Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction. Exp Clin Psychopharmacol 18:297-304. – reference: Cox LS, Tiffany ST, Christen AG (2001) Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tob Res 3:7-16. – reference: Lorberbaum JP, Kose S, Johnson MR, Arana GW, Sullivan LK, Hamner MB, Ballenger JC, Lydiard RB, Brodrick PS, Bohning DE, George MS (2004) Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport 15:2701-2705. – reference: Frascella J, Potenza MN, Brown LL, Childress AR (2010) Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint? Ann N Y Acad Sci 1187:294-315. – reference: McClernon FJ, Kozink RV, Lutz AM, Rose JE (2009) 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. Psychopharmacology (Berl) 204:25-35. – reference: Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE (2005) Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. 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Neuroimage 54:2374-2381. – reference: Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT (2000) Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 10:120-131. – reference: Park MS, Sohn JH, Suk JA, Kim SH, Sohn S, Sparacio R (2007) Brain substrates of craving to alcohol cues in subjects with alcohol use disorder. Alcohol Alcohol 42:417-422. – reference: Pearson JM, Heilbronner SR, Barack DL, Hayden BY, Platt ML (2011) Posterior cingulate cortex: adapting behavior to a changing world. Trends Cogn Sci 15:143-151. – reference: Rorden C, Brett M (2000) Stereotaxic display of brain lesions. Behav Neurol 12:191-200. – reference: Sinha R, Li CS (2007) Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications. Drug Alcohol Rev 26:25-31. – reference: Talairach J, Tournoux P (1998) Co-Planar Stereotaxic Atlas of the Human Brain. 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volume: 63 start-page: 218 year: 2009 end-page: 224 article-title: The association between harmful alcohol use and Internet addiction among college students: comparison of personality publication-title: Psychiatry Clin Neurosci – volume: 129 start-page: 564 year: 2006 end-page: 583 article-title: The precuneus: a review of its functional anatomy and behavioural correlates publication-title: Brain – volume: 1187 start-page: 294 year: 2010 end-page: 315 article-title: Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint? publication-title: Ann N Y Acad Sci – volume: 51 start-page: 887 year: 2006 end-page: 894 article-title: Tridimensional personality of adolescents with internet addiction and substance use experience publication-title: Can J Psychiatry – volume: 17 start-page: 365 year: 2009 end-page: 373 article-title: Brain fMRI reactivity to smoking‐related images before and during extended smoking abstinence publication-title: Exp Clin Psychopharmacol – volume: 54 start-page: 93 year: 1999 end-page: 105 article-title: Self‐reports: how questions shape answers publication-title: Am Psychol – volume: 53 start-page: 133 year: 1993 end-page: 149 article-title: Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioural paradigms involving memory and selective attention publication-title: Behav Brain Res – volume: 32 start-page: 748 year: 2010 end-page: 755 article-title: Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit publication-title: Bioessays – article-title: The association between Internet addiction and psychiatric disorder: a review of the literature publication-title: Eur Psychiatry – volume: 158 start-page: 1075 year: 2001 end-page: 1083 article-title: Subcortical correlates of craving in recently abstinent alcoholic patients publication-title: Am J Psychiatry – volume: 212 start-page: 181 year: 2007 end-page: 194 article-title: Orienting and maintenance of spatial attention in audition and vision: multimodal and modality‐specific brain activations publication-title: Brain Struct Funct – volume: 26 start-page: 1097 year: 2005 end-page: 1108 article-title: Neural correlates of high and craving during cocaine self‐administration using BOLD fMRI publication-title: Neuroimage – year: 1998 – volume: 10 start-page: 120 year: 2000 end-page: 131 article-title: Automated Talairach atlas labels for functional brain mapping publication-title: Hum Brain Mapp – volume: 204 start-page: 25 year: 2009 end-page: 35 article-title: 24‐h smoking abstinence potentiates fMRI‐BOLD activation to smoking cues in cerebral cortex and dorsal striatum publication-title: Psychopharmacology (Berl) – volume: 15 start-page: 143 year: 2011 end-page: 151 article-title: Posterior cingulate cortex: adapting behavior to a changing world publication-title: Trends Cogn Sci – volume: 16 start-page: 573 year: 2009 end-page: 585 article-title: Context representations, context functions, and the parahippocampal‐hippocampal system publication-title: Learn Mem – volume: 50 start-page: 378 year: 2009b end-page: 384 article-title: Proposed diagnostic criteria and the screening and diagnosing tool of Internet addiction in college students publication-title: Compr Psychiatry – volume: 184 start-page: 577 year: 2006 end-page: 588 article-title: Severity of nicotine dependence modulates cue‐induced brain activity in regions involved in motor preparation and imagery publication-title: Psychopharmacology (Berl) – volume: 22 start-page: 310 year: 1999 end-page: 316 article-title: The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain publication-title: Trends Neurosci – year: 2002 – volume: 162 start-page: 1403 year: 2005 end-page: 1413 article-title: The neural basis of addiction: a pathology of motivation and choice publication-title: Am J Psychiatry – volume: 42 start-page: 417 year: 2007 end-page: 422 article-title: Brain substrates of craving to alcohol cues in subjects with alcohol use disorder publication-title: Alcohol Alcohol – volume: 58 start-page: 334 year: 2001 end-page: 341 article-title: Neural activity related to drug craving in cocaine addiction publication-title: Arch Gen Psychiatry – volume: 34 start-page: 19 year: 1993 end-page: 28 article-title: The development of a cocaine craving questionnaire publication-title: Drug Alcohol Depend – volume: 48 start-page: 74 year: 2005 end-page: 97 article-title: Cue reactivity in nicotine and tobacco dependence: a “multiple‐action” model of nicotine as a primary reinforcement and as an enhancer of the effects of smoking‐associated stimuli publication-title: Brain Res Brain Res Rev – volume: 54 start-page: 2374 year: 2011 end-page: 2381 article-title: Neurobiological substrate of smoking‐related attentional bias publication-title: 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This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects... This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in... This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in... |
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SubjectTerms | Addiction Behavior, Addictive - pathology Brain - pathology Brain Diseases - pathology Craving for online gaming cue reactivity Cues Humans Internet Internet gaming addiction Magnetic Resonance Imaging Male parahippocampus remission Video Games Young Adult |
Title | Brain correlates of craving for online gaming under cue exposure in subjects with Internet gaming addiction and in remitted subjects |
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