Brain correlates of craving for online gaming under cue exposure in subjects with Internet gaming addiction and in remitted subjects

ABSTRACT This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs)....

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Published inAddiction biology Vol. 18; no. 3; pp. 559 - 569
Main Authors Ko, Chih-Hung, Liu, Gin-Chung, Yen, Ju-Yu, Chen, Chiao-Yun, Yen, Cheng-Fang, Chen, Cheng-Sheng
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.05.2013
John Wiley & Sons, Inc
Subjects
Online AccessGet full text
ISSN1355-6215
1369-1600
1369-1600
DOI10.1111/j.1369-1600.2011.00405.x

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Abstract ABSTRACT This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region‐of‐interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies.
AbstractList ABSTRACT This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region‐of‐interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies.
This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event‐related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region‐of‐interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies.
This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event-related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region-of-interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies.This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event-related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region-of-interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies.
This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event-related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region-of-interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies. [PUBLICATION ABSTRACT]
Author Yen, Cheng-Fang
Ko, Chih-Hung
Liu, Gin-Chung
Chen, Cheng-Sheng
Chen, Chiao-Yun
Yen, Ju-Yu
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  surname: Ko
  fullname: Ko, Chih-Hung
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  fullname: Liu, Gin-Chung
  email: gcliu@kmu.edu.tw
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  fullname: Yen, Cheng-Fang
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References Rudy JW (2009) Context representations, context functions, and the parahippocampal-hippocampal system. Learn Mem 16:573-585.
Chen SH, Weng LC, Su YJ, Wu HM, Yang PF (2003) Development of Chinese Internet addiction scale and its psychometric study. Chin J Psychol 45:279-294.
Schneider F, Habel U, Wagner M, Franke P, Salloum JB, Shah NJ. Toni I, Sulzbach C, Hönig K, Maier W, Gaebel W, Zilles K (2001) Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiatry 158:1075-1083.
Cox LS, Tiffany ST, Christen AG (2001) Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tob Res 3:7-16.
Ko CH, Yen JY, Yen CF, Chen CS, Chen CC (in press) The association between Internet addiction and psychiatric disorder: a review of the literature. Eur Psychiatry.
Tiffany ST, Singleton E, Haertzen CA, Henningfield JE (1993) The development of a cocaine craving questionnaire. Drug Alcohol Depend 34:19-28.
Lorberbaum JP, Kose S, Johnson MR, Arana GW, Sullivan LK, Hamner MB, Ballenger JC, Lydiard RB, Brodrick PS, Bohning DE, George MS (2004) Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport 15:2701-2705.
Schwartz N (1999) Self-reports: how questions shape answers. Am Psychol 54:93-105.
Risinger RC, Salmeron BJ, Ross TJ, Amen SL, Sanfilipo M, Hoffmann RG, Bloom AS, Garavan H, Stein EA (2005) Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage 26:1097-1108.
Crockford DN, Goodyear B, Edwards J, Quickfall J, el-Guebaly N (2005) Cue-induced brain activity in pathological gamblers. Biol Psychiatry 58:787-795.
Han DH, Hwang JW, Renshaw PF (2010) Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction. Exp Clin Psychopharmacol 18:297-304.
Smolka MN, Buhler M, Klein S, Zimmermann U, Mann K, Heinz A, Braus DF (2006) Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery. Psychopharmacology (Berl) 184:577-588.
Chiamulera C (2005) Cue reactivity in nicotine and tobacco dependence: a "multiple-action" model of nicotine as a primary reinforcement and as an enhancer of the effects of smoking-associated stimuli. Brain Res Brain Res Rev 48:74-97.
Park MS, Sohn JH, Suk JA, Kim SH, Sohn S, Sparacio R (2007) Brain substrates of craving to alcohol cues in subjects with alcohol use disorder. Alcohol Alcohol 42:417-422.
Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE (2005) Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. Psychopharmacology (Berl) 183:171-180.
Skinner MD, Aubin HJ (2010) Craving's place in addiction theory: contributions of the major models. Neurosci Biobehav Rev 34:606-623.
Ko CH, Liu GC, Hsiao S, Yen JY, Yang MJ, Lin WC, Yen CF, Chen CS (2009a) Brain activities associated with gaming urge of online gaming addiction. J Psychiatr Res 43:739-747.
McClernon FJ, Hiott FB, Liu J, Salley AN, Behm FM, Rose JE (2007) Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study. Addict Biol 12:503-512.
McCormack HM, Horne DJ, Sheather S (1988) Clinical applications of visual analogue scales: a critical review. Psychol Med 18:1007-1019.
Sinha R, Li CS (2007) Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications. Drug Alcohol Rev 26:25-31.
Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403-1413.
Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F, Baler R (2010) Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit. Bioessays 32:748-755.
Kilts CD, Schweitzer JB, Quinn CK, Gross RE, Faber TL, Muhammad F, Ely TD, Hoffman JM, Drexler KP (2001) Neural activity related to drug craving in cocaine addiction. Arch Gen Psychiatry 58:334-341.
Maddock RJ (1999) The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends Neurosci 22:310-316.
Mitchell DG (2011) The nexus between decision making and emotion regulation: a review of convergent neurocognitive substrates. Behav Brain Res 217:215-231.
Salzmann E, Vidyasagar TR, Creutzfeldt OD (1993) Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioural paradigms involving memory and selective attention. Behav Brain Res 53:133-149.
Robinson TE, Berridge KC (2008) Review The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci 363:3137-3146.
Frascella J, Potenza MN, Brown LL, Childress AR (2010) Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint? Ann N Y Acad Sci 1187:294-315.
Ko CH, Yen JY, Chen SH, Yang MJ, Lin HC, Yen CF (2009b) Proposed diagnostic criteria and the screening and diagnosing tool of Internet addiction in college students. Compr Psychiatry 50:378-384.
Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT (2000) Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 10:120-131.
McClernon FJ, Kozink RV, Lutz AM, Rose JE (2009) 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. Psychopharmacology (Berl) 204:25-35.
Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129:564-583.
Rorden C, Brett M (2000) Stereotaxic display of brain lesions. Behav Neurol 12:191-200.
Heinz A, Beck A, Grusser SM, Grace AA, Wrase J (2009) Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol 14:108-118.
Luijten M, Veltman DJ, van den Brink W, Hester R, Field M, Smits M, Franken IH (2011) Neurobiological substrate of smoking-related attentional bias. Neuroimage 54:2374-2381.
Salmi J, Rinne T, Degerman A, Salonen O, Alho K (2007) Orienting and maintenance of spatial attention in audition and vision: multimodal and modality-specific brain activations. Brain Struct Funct 212:181-194.
Talairach J, Tournoux P (1998) Co-Planar Stereotaxic Atlas of the Human Brain. Stuttgart: Georg Thieme Verlag.
Yen JY, Ko CH, Yen CF, Chen CS, Chen CC (2009) The association between harmful alcohol use and Internet addiction among college students: comparison of personality. Psychiatry Clin Neurosci 63:218-224.
American Psychiatric Assn (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Text Revision. Washington, DC: American Psychiatric Association.
Rosenberg H (2009) Clinical and laboratory assessment of the subjective experience of drug craving. Clin Psychol Rev 29:519-534.
Goudriaan AE, de Ruiter MB, van den Brink W, Oosterlaan J, Veltman DJ (2010) Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict Biol 15:491-503.
Ko CH, Yen JY, Chen CC, Chen SH, Wu K, Yen CF (2006) Tridimensional personality of adolescents with internet addiction and substance use experience. Can J Psychiatry 51:887-894.
Janes AC, Frederick B, Richardt S, Burbridge C, Merlo-Pich E, Renshaw PF, Evins AE, Fava M, Kaufman MJ (2009) Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence. Exp Clin Psychopharmacol 17:365-373.
Pearson JM, Heilbronner SR, Barack DL, Hayden BY, Platt ML (2011) Posterior cingulate cortex: adapting behavior to a changing world. Trends Cogn Sci 15:143-151.
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References_xml – reference: Chen SH, Weng LC, Su YJ, Wu HM, Yang PF (2003) Development of Chinese Internet addiction scale and its psychometric study. Chin J Psychol 45:279-294.
– reference: Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F, Baler R (2010) Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit. Bioessays 32:748-755.
– reference: Ko CH, Liu GC, Hsiao S, Yen JY, Yang MJ, Lin WC, Yen CF, Chen CS (2009a) Brain activities associated with gaming urge of online gaming addiction. J Psychiatr Res 43:739-747.
– reference: Schneider F, Habel U, Wagner M, Franke P, Salloum JB, Shah NJ. Toni I, Sulzbach C, Hönig K, Maier W, Gaebel W, Zilles K (2001) Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiatry 158:1075-1083.
– reference: Rudy JW (2009) Context representations, context functions, and the parahippocampal-hippocampal system. Learn Mem 16:573-585.
– reference: Janes AC, Frederick B, Richardt S, Burbridge C, Merlo-Pich E, Renshaw PF, Evins AE, Fava M, Kaufman MJ (2009) Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence. Exp Clin Psychopharmacol 17:365-373.
– reference: McClernon FJ, Hiott FB, Liu J, Salley AN, Behm FM, Rose JE (2007) Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study. Addict Biol 12:503-512.
– reference: Salmi J, Rinne T, Degerman A, Salonen O, Alho K (2007) Orienting and maintenance of spatial attention in audition and vision: multimodal and modality-specific brain activations. Brain Struct Funct 212:181-194.
– reference: American Psychiatric Assn (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Text Revision. Washington, DC: American Psychiatric Association.
– reference: Salzmann E, Vidyasagar TR, Creutzfeldt OD (1993) Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioural paradigms involving memory and selective attention. Behav Brain Res 53:133-149.
– reference: Kalivas PW, Volkow ND (2005) The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162:1403-1413.
– reference: Schwartz N (1999) Self-reports: how questions shape answers. Am Psychol 54:93-105.
– reference: Ko CH, Yen JY, Yen CF, Chen CS, Chen CC (in press) The association between Internet addiction and psychiatric disorder: a review of the literature. Eur Psychiatry.
– reference: Risinger RC, Salmeron BJ, Ross TJ, Amen SL, Sanfilipo M, Hoffmann RG, Bloom AS, Garavan H, Stein EA (2005) Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. Neuroimage 26:1097-1108.
– reference: Skinner MD, Aubin HJ (2010) Craving's place in addiction theory: contributions of the major models. Neurosci Biobehav Rev 34:606-623.
– reference: Smolka MN, Buhler M, Klein S, Zimmermann U, Mann K, Heinz A, Braus DF (2006) Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery. Psychopharmacology (Berl) 184:577-588.
– reference: Maddock RJ (1999) The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain. Trends Neurosci 22:310-316.
– reference: Chiamulera C (2005) Cue reactivity in nicotine and tobacco dependence: a "multiple-action" model of nicotine as a primary reinforcement and as an enhancer of the effects of smoking-associated stimuli. Brain Res Brain Res Rev 48:74-97.
– reference: Heinz A, Beck A, Grusser SM, Grace AA, Wrase J (2009) Identifying the neural circuitry of alcohol craving and relapse vulnerability. Addict Biol 14:108-118.
– reference: Ko CH, Yen JY, Chen CC, Chen SH, Wu K, Yen CF (2006) Tridimensional personality of adolescents with internet addiction and substance use experience. Can J Psychiatry 51:887-894.
– reference: Rosenberg H (2009) Clinical and laboratory assessment of the subjective experience of drug craving. Clin Psychol Rev 29:519-534.
– reference: Kilts CD, Schweitzer JB, Quinn CK, Gross RE, Faber TL, Muhammad F, Ely TD, Hoffman JM, Drexler KP (2001) Neural activity related to drug craving in cocaine addiction. Arch Gen Psychiatry 58:334-341.
– reference: Mitchell DG (2011) The nexus between decision making and emotion regulation: a review of convergent neurocognitive substrates. Behav Brain Res 217:215-231.
– reference: Ko CH, Yen JY, Chen SH, Yang MJ, Lin HC, Yen CF (2009b) Proposed diagnostic criteria and the screening and diagnosing tool of Internet addiction in college students. Compr Psychiatry 50:378-384.
– reference: Tiffany ST, Singleton E, Haertzen CA, Henningfield JE (1993) The development of a cocaine craving questionnaire. Drug Alcohol Depend 34:19-28.
– reference: Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129:564-583.
– reference: Robinson TE, Berridge KC (2008) Review The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci 363:3137-3146.
– reference: Han DH, Hwang JW, Renshaw PF (2010) Bupropion sustained release treatment decreases craving for video games and cue-induced brain activity in patients with Internet video game addiction. Exp Clin Psychopharmacol 18:297-304.
– reference: Cox LS, Tiffany ST, Christen AG (2001) Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tob Res 3:7-16.
– reference: Lorberbaum JP, Kose S, Johnson MR, Arana GW, Sullivan LK, Hamner MB, Ballenger JC, Lydiard RB, Brodrick PS, Bohning DE, George MS (2004) Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport 15:2701-2705.
– reference: Frascella J, Potenza MN, Brown LL, Childress AR (2010) Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint? Ann N Y Acad Sci 1187:294-315.
– reference: McClernon FJ, Kozink RV, Lutz AM, Rose JE (2009) 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. Psychopharmacology (Berl) 204:25-35.
– reference: Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE (2005) Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. Psychopharmacology (Berl) 183:171-180.
– reference: McCormack HM, Horne DJ, Sheather S (1988) Clinical applications of visual analogue scales: a critical review. Psychol Med 18:1007-1019.
– reference: Yen JY, Ko CH, Yen CF, Chen CS, Chen CC (2009) The association between harmful alcohol use and Internet addiction among college students: comparison of personality. Psychiatry Clin Neurosci 63:218-224.
– reference: Crockford DN, Goodyear B, Edwards J, Quickfall J, el-Guebaly N (2005) Cue-induced brain activity in pathological gamblers. Biol Psychiatry 58:787-795.
– reference: Goudriaan AE, de Ruiter MB, van den Brink W, Oosterlaan J, Veltman DJ (2010) Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict Biol 15:491-503.
– reference: Luijten M, Veltman DJ, van den Brink W, Hester R, Field M, Smits M, Franken IH (2011) Neurobiological substrate of smoking-related attentional bias. Neuroimage 54:2374-2381.
– reference: Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT (2000) Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp 10:120-131.
– reference: Park MS, Sohn JH, Suk JA, Kim SH, Sohn S, Sparacio R (2007) Brain substrates of craving to alcohol cues in subjects with alcohol use disorder. Alcohol Alcohol 42:417-422.
– reference: Pearson JM, Heilbronner SR, Barack DL, Hayden BY, Platt ML (2011) Posterior cingulate cortex: adapting behavior to a changing world. Trends Cogn Sci 15:143-151.
– reference: Rorden C, Brett M (2000) Stereotaxic display of brain lesions. Behav Neurol 12:191-200.
– reference: Sinha R, Li CS (2007) Imaging stress- and cue-induced drug and alcohol craving: association with relapse and clinical implications. Drug Alcohol Rev 26:25-31.
– reference: Talairach J, Tournoux P (1998) Co-Planar Stereotaxic Atlas of the Human Brain. Stuttgart: Georg Thieme Verlag.
– volume: 43
  start-page: 739
  year: 2009a
  end-page: 747
  article-title: Brain activities associated with gaming urge of online gaming addiction
  publication-title: J Psychiatr Res
– volume: 12
  start-page: 503
  year: 2007
  end-page: 512
  article-title: Selectively reduced responses to smoking cues in amygdala following extinction‐based smoking cessation: results of a preliminary functional magnetic resonance imaging study
  publication-title: Addict Biol
– volume: 15
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  year: 2004
  end-page: 2705
  article-title: Neural correlates of speech anticipatory anxiety in generalized social phobia
  publication-title: Neuroreport
– volume: 12
  start-page: 191
  year: 2000
  end-page: 200
  article-title: Stereotaxic display of brain lesions
  publication-title: Behav Neurol
– volume: 3
  start-page: 7
  year: 2001
  end-page: 16
  article-title: Evaluation of the brief questionnaire of smoking urges (QSU‐brief) in laboratory and clinical settings
  publication-title: Nicotine Tob Res
– volume: 58
  start-page: 787
  year: 2005
  end-page: 795
  article-title: Cue‐induced brain activity in pathological gamblers
  publication-title: Biol Psychiatry
– volume: 34
  start-page: 606
  year: 2010
  end-page: 623
  article-title: Craving's place in addiction theory: contributions of the major models
  publication-title: Neurosci Biobehav Rev
– volume: 45
  start-page: 279
  year: 2003
  end-page: 294
  article-title: Development of Chinese Internet addiction scale and its psychometric study
  publication-title: Chin J Psychol
– volume: 18
  start-page: 297
  year: 2010
  end-page: 304
  article-title: Bupropion sustained release treatment decreases craving for video games and cue‐induced brain activity in patients with Internet video game addiction
  publication-title: Exp Clin Psychopharmacol
– volume: 363
  start-page: 3137
  year: 2008
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  article-title: Review The incentive sensitization theory of addiction: some current issues
  publication-title: Philos Trans R Soc Lond B Biol Sci
– year: 2000
– volume: 63
  start-page: 218
  year: 2009
  end-page: 224
  article-title: The association between harmful alcohol use and Internet addiction among college students: comparison of personality
  publication-title: Psychiatry Clin Neurosci
– volume: 129
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  year: 2006
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  article-title: The precuneus: a review of its functional anatomy and behavioural correlates
  publication-title: Brain
– volume: 1187
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  year: 2010
  end-page: 315
  article-title: Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint?
  publication-title: Ann N Y Acad Sci
– volume: 51
  start-page: 887
  year: 2006
  end-page: 894
  article-title: Tridimensional personality of adolescents with internet addiction and substance use experience
  publication-title: Can J Psychiatry
– volume: 17
  start-page: 365
  year: 2009
  end-page: 373
  article-title: Brain fMRI reactivity to smoking‐related images before and during extended smoking abstinence
  publication-title: Exp Clin Psychopharmacol
– volume: 54
  start-page: 93
  year: 1999
  end-page: 105
  article-title: Self‐reports: how questions shape answers
  publication-title: Am Psychol
– volume: 53
  start-page: 133
  year: 1993
  end-page: 149
  article-title: Functional comparison of neuronal properties in the primate posterior hippocampus and parahippocampus (area TF/TH) during different behavioural paradigms involving memory and selective attention
  publication-title: Behav Brain Res
– volume: 32
  start-page: 748
  year: 2010
  end-page: 755
  article-title: Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit
  publication-title: Bioessays
– article-title: The association between Internet addiction and psychiatric disorder: a review of the literature
  publication-title: Eur Psychiatry
– volume: 158
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  year: 2001
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  article-title: Subcortical correlates of craving in recently abstinent alcoholic patients
  publication-title: Am J Psychiatry
– volume: 212
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  year: 2007
  end-page: 194
  article-title: Orienting and maintenance of spatial attention in audition and vision: multimodal and modality‐specific brain activations
  publication-title: Brain Struct Funct
– volume: 26
  start-page: 1097
  year: 2005
  end-page: 1108
  article-title: Neural correlates of high and craving during cocaine self‐administration using BOLD fMRI
  publication-title: Neuroimage
– year: 1998
– volume: 10
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  year: 2000
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  publication-title: Hum Brain Mapp
– volume: 204
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  year: 2009
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Snippet ABSTRACT This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects...
This study aimed to evaluate brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in...
This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in...
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SubjectTerms Addiction
Behavior, Addictive - pathology
Brain - pathology
Brain Diseases - pathology
Craving for online gaming
cue reactivity
Cues
Humans
Internet
Internet gaming addiction
Magnetic Resonance Imaging
Male
parahippocampus
remission
Video Games
Young Adult
Title Brain correlates of craving for online gaming under cue exposure in subjects with Internet gaming addiction and in remitted subjects
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https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1369-1600.2011.00405.x
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Volume 18
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