Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF‐1α regulator

• Published in: Cancer science Vol. 112; no. 4; pp. 1614 - 1623
• Main Authors: Isomura, Hisanori, Taguchi, Ayumu, Kajino, Taisuke, Asai, Naoya, Nakatochi, Masahiro, Kato, Seiichi, Suzuki, Keiko, Yanagisawa, Kiyoshi, Suzuki, Motoshi, Fujishita, Teruaki, Yamaguchi, Tomoya, Takahashi, Masahide, Takahashi, Takashi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2021; John Wiley and Sons Inc
• Subjects: Adenocarcinoma; Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - pathology; Age; Animals; Cell Line, Tumor; Cloning; Deoxyribonucleic acid; DNA; Down-Regulation - genetics; EGFR; Epidermal growth factor receptors; Fibroblasts; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene set enrichment analysis; Genetic engineering; Genetic testing; genetically engineered mouse model; HIF‐1α; Humans; Hypoxia; Hypoxia - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Kinases; Laboratories; lung adenocarcinoma; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oncogenes - genetics; Original; ORIGINAL ARTICLES; Proteins; Receptor Tyrosine Kinase-like Orphan Receptors - genetics; ROR1; Signal Transduction - genetics; Solid tumors; Surfactants; Therapeutic targets; Thyroid Nuclear Factor 1 - genetics; Transgenic animals; Tumor cell lines; Tumor microenvironment; Tumor Microenvironment - genetics; Tumors; Vertebrae; HIF-1α; ROR1; EGFR; genetically engineered mouse model; lung adenocarcinoma

We previously reported that ROR1 is a crucial downstream gene for the TTF‐1/NKX2‐1 lineage‐survival oncogene in lung adenocarcinoma, while others have found altered expression of ROR1 in multiple cancer types. Accumulated evidence therefore indicates ROR1 as an attractive molecular target, though it...