Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF‐1α regulator - Isomura, Hisanori; Taguchi, Ayumu; Kajino, Taisuke; Asai, Naoya; Nakatochi, Masahiro; Kato, Seiichi; Suzuki, Keiko; Yanagisawa, Kiyoshi; Suzuki, Motoshi; Fujishita, Teruaki; Yamaguchi, Tomoya; Takahashi, Masahide; et al. (Cancer science, 2021)
Keywords: Adenocarcinoma; Adenocarcinoma of Lung - genetics; Adenocarcinoma of Lung - pathology; Age; Animals; Cell Line, Tumor; Cloning; Deoxyribonucleic acid; DNA; Down-Regulation - genetics; EGFR; Epidermal growth factor receptors; Fibroblasts; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Gene set enrichment analysis; Genetic engineering; Genetic testing; genetically engineered mouse model; HIF‐1α; Humans; Hypoxia; Hypoxia - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Kinases; Laboratories; lung adenocarcinoma; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Oncogenes - genetics; Original; ORIGINAL ARTICLES; Proteins; Receptor Tyrosine Kinase-like Orphan Receptors - genetics; ROR1; Signal Transduction - genetics; Solid tumors; Surfactants; Therapeutic targets; Thyroid Nuclear Factor 1 - genetics; Transgenic animals; Tumor cell lines; Tumor microenvironment; Tumor Microenvironment - genetics; Tumors; Vertebrae; HIF-1α; ROR1; EGFR; genetically engineered mouse model; lung adenocarcinoma