Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase)

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 71; no. 4; pp. 761 - 770
• Main Authors: Etwebi, Zienab, Landesberg, Gavin, Preston, Kyle, Eguchi, Satoru, Scalia, Rosario
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.04.2018
• Subjects: Animals; Animals, Genetically Modified; Aorta - metabolism; Aorta - pathology; Calpain - metabolism; Cell Adhesion - physiology; Cell Adhesion Molecules - metabolism; Cell Culture Techniques; Endothelial Cells - immunology; Endothelial Cells - metabolism; Inflammation - immunology; Leukocytes - physiology; Mice; Peroxidase - metabolism; Protein Phosphatase 2 - metabolism; Signal Transduction; Up-Regulation; Vascular Diseases - immunology; Vascular Diseases - metabolism; calpain; cell adhesion molecules; endothelial cells; inflammation; peroxidase

MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. The molecular mechanisms of the endothelial damaging action of MPO remain though largely elusive. Calpain is a calcium-d...