Clinical Profiles of DFNA11 at Diverse Stages of Development and Aging in a Large Family Identified by Linkage Analysis

• Published in: Otology & neurotology Vol. 41; no. 6; p. e663
• Main Authors: Yamamoto, Nobuko, Mutai, Hideki, Namba, Kazunori, Goto, Fumiyuki, Ogawa, Kaoru, Matsunaga, Tatsuo
• Format: Journal Article
• Language: English
• Published: United States 01.07.2020
• Subjects: Adult; Aging; Child; Hearing Loss, Sensorineural - diagnosis; Hearing Loss, Sensorineural - genetics; Humans; Myosin VIIa - genetics; Myosins - genetics; Otoacoustic Emissions, Spontaneous; Pedigree

The phenotype of DFNA11 consists of specific features at diverse developmental and age stages. Only eight mutations have been identified for autosomal dominant non-syndromic hearing loss related to MYO7A (DFNA11), and the onset and progression of DFNA11 are poorly understood. After linkage analysis...