Human mesenchymal stem‐derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat

• Published in: Clinical and translational medicine Vol. 13; no. 6; pp. e1284 - n/a
• Main Authors: Nakazaki, Masahito, Lankford, Karen L., Yamamoto, Hideaki, Mae, Yoshiyuki, Kocsis, Jeffery D.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2023; John Wiley and Sons Inc; Wiley
• Subjects: Animals; body growth; Bone marrow; Clinical medicine; Cytokines; Cytokines - metabolism; Extracellular vesicles; Extracellular Vesicles - metabolism; Humans; Insulin-like growth factors; Interleukin-6 - metabolism; Laboratory animals; mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Penicillin; Proteins; Rats; Spinal cord injuries; Spinal Cord Injuries - therapy; spinal cord injury; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Young adults; United States > US; spinal cord injury; extracellular vesicles; body growth; mesenchymal stem cells

Background Spinal cord injury (SCI) in young adults leads to severe sensorimotor disabilities as well as slowing of growth. Systemic pro‐inflammatory cytokines are associated with growth failure and muscle wasting. Here we investigated whether intravenous (IV) delivery of small extracellular vesicle...