Further Evaluation of Rizatriptan in Menstrual Migraine: Retrospective Analysis of Long-term Data
Objective.—To determine the long‐term efficacy of oral rizatriptan 10‐mg wafers in the treatment of menstrual migraine attacks. Methods.—Data from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 mon...
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Published in | Headache Vol. 42; no. 9; pp. 917 - 923 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Boston, MA, USA
Blackwell Science Inc
01.10.2002
Blackwell |
Subjects | |
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Abstract | Objective.—To determine the long‐term efficacy of oral rizatriptan 10‐mg wafers in the treatment of menstrual migraine attacks.
Methods.—Data from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 months were included in a retrospective analysis. Patients used a diary card to record details of each migraine attack and onset of menstruation. Attacks in women were classified as menstrual or nonmenstrual according to 3 time windows relative to onset of menstruation (day 0): −3 to +3 days (7‐day window), −2 to + 2 days (5‐day window), and 0 to +1 days (2‐day window). The analysis looked at the efficacy of rizatriptan 10 mg by menstrual category of attack for each definition on three measures: pain relief at 2 hours (reduction of pain to mild or none), pain free at 2 hours, 24‐hours sustained pain free (pain free at 2 hours with no headache recurrence and no use of additional medications from 2 to 24 hours).
Results.—Ninety‐five women used rizatriptan 10 mg to treat a total of 1,839 attacks. The percentage of menstrual attacks was 30% for the –3 to +3 days definition, 23% for the −2 to +2 days definition, and 11% for the 0 to +1 days definition. Rizatriptan 10 mg was equally effective in menstrual and nonmenstrual migraine attacks regardless of the definition used. For example, using the −3 to +3 days definition, 78% of menstrual migraine attacks were relieved at 2 hours after dosing compared with 78% of nonmenstrual attacks. Pain relief rates for the other definitions were as follows: −2 to +2 days, menstrual = 78%, nonmenstrual = 78%; 0 to +1 days, menstrual = 79%, and nonmenstrual = 78%. No differences between menstrual and nonmenstrual attacks were found for the 2‐hour pain free and 24‐hour sustained pain free measures for any of the three definitions.
Conclusion.—Rizatriptan 10‐mg wafers were equally effective in the treatment of menstrual and nonmenstrual migraine attacks occurring over 6 months, regardless of the precise definition of menstrual association used and even when the outcome criteria were very stringent. These data provide further evidence that triptans are effective treatments for menstrual migraine. |
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AbstractList | Objective.-To determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks. Methods.-Data from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 months were included in a retrospective analysis. Patients used a diary card to record details of each migraine attack and onset of menstruation. Attacks in women were classified as menstrual or nonmenstrual according to 3 time windows relative to onset of menstruation (day 0): -3 to +3 days (7-day window), -2 to + 2 days (5-day window), and 0 to +1 days (2-day window). The analysis looked at the efficacy of rizatriptan 10 mg by menstrual category of attack for each definition on three measures: pain relief at 2 hours (reduction of pain to mild or none), pain free at 2 hours, 24-hours sustained pain free (pain free at 2 hours with no headache recurrence and no use of additional medications from 2 to 24 hours). Results.-Ninety-five women used rizatriptan 10 mg to treat a total of 1,839 attacks. The percentage of menstrual attacks was 30% for the -3 to +3 days definition, 23% for the -2 to +2 days definition, and 11% for the 0 to +1 days definition. Rizatriptan 10 mg was equally effective in menstrual and nonmenstrual migraine attacks regardless of the definition used. For example, using the -3 to +3 days definition, 78% of menstrual migraine attacks were relieved at 2 hours after dosing compared with 78% of nonmenstrual attacks. Pain relief rates for the other definitions were as follows: -2 to +2 days, menstrual=78%, nonmenstrual=78%; 0 to +1 days, menstrual=79%, and nonmenstrual=78%. No differences between menstrual and nonmenstrual attacks were found for the 2-hour pain free and 24-hour sustained pain free measures for any of the three definitions. Conclusion.-Rizatriptan 10-mg wafers were equally effective in the treatment of menstrual and nonmenstrual migraine attacks occurring over 6 months, regardless of the precise definition of menstrual association used and even when the outcome criteria were very stringent. These data provide further evidence that triptans are effective treatments for menstrual migraine. Objective.—To determine the long‐term efficacy of oral rizatriptan 10‐mg wafers in the treatment of menstrual migraine attacks. Methods.—Data from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 months were included in a retrospective analysis. Patients used a diary card to record details of each migraine attack and onset of menstruation. Attacks in women were classified as menstrual or nonmenstrual according to 3 time windows relative to onset of menstruation (day 0): −3 to +3 days (7‐day window), −2 to + 2 days (5‐day window), and 0 to +1 days (2‐day window). The analysis looked at the efficacy of rizatriptan 10 mg by menstrual category of attack for each definition on three measures: pain relief at 2 hours (reduction of pain to mild or none), pain free at 2 hours, 24‐hours sustained pain free (pain free at 2 hours with no headache recurrence and no use of additional medications from 2 to 24 hours). Results.—Ninety‐five women used rizatriptan 10 mg to treat a total of 1,839 attacks. The percentage of menstrual attacks was 30% for the –3 to +3 days definition, 23% for the −2 to +2 days definition, and 11% for the 0 to +1 days definition. Rizatriptan 10 mg was equally effective in menstrual and nonmenstrual migraine attacks regardless of the definition used. For example, using the −3 to +3 days definition, 78% of menstrual migraine attacks were relieved at 2 hours after dosing compared with 78% of nonmenstrual attacks. Pain relief rates for the other definitions were as follows: −2 to +2 days, menstrual = 78%, nonmenstrual = 78%; 0 to +1 days, menstrual = 79%, and nonmenstrual = 78%. No differences between menstrual and nonmenstrual attacks were found for the 2‐hour pain free and 24‐hour sustained pain free measures for any of the three definitions. Conclusion.—Rizatriptan 10‐mg wafers were equally effective in the treatment of menstrual and nonmenstrual migraine attacks occurring over 6 months, regardless of the precise definition of menstrual association used and even when the outcome criteria were very stringent. These data provide further evidence that triptans are effective treatments for menstrual migraine. Objective .—To determine the long‐term efficacy of oral rizatriptan 10‐mg wafers in the treatment of menstrual migraine attacks. Methods .—Data from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 months were included in a retrospective analysis. Patients used a diary card to record details of each migraine attack and onset of menstruation. Attacks in women were classified as menstrual or nonmenstrual according to 3 time windows relative to onset of menstruation (day 0): −3 to +3 days (7‐day window), −2 to + 2 days (5‐day window), and 0 to +1 days (2‐day window). The analysis looked at the efficacy of rizatriptan 10 mg by menstrual category of attack for each definition on three measures: pain relief at 2 hours (reduction of pain to mild or none), pain free at 2 hours, 24‐hours sustained pain free (pain free at 2 hours with no headache recurrence and no use of additional medications from 2 to 24 hours). Results .—Ninety‐five women used rizatriptan 10 mg to treat a total of 1,839 attacks. The percentage of menstrual attacks was 30% for the –3 to +3 days definition, 23% for the −2 to +2 days definition, and 11% for the 0 to +1 days definition. Rizatriptan 10 mg was equally effective in menstrual and nonmenstrual migraine attacks regardless of the definition used. For example, using the −3 to +3 days definition, 78% of menstrual migraine attacks were relieved at 2 hours after dosing compared with 78% of nonmenstrual attacks. Pain relief rates for the other definitions were as follows: −2 to +2 days, menstrual = 78%, nonmenstrual = 78%; 0 to +1 days, menstrual = 79%, and nonmenstrual = 78%. No differences between menstrual and nonmenstrual attacks were found for the 2‐hour pain free and 24‐hour sustained pain free measures for any of the three definitions. Conclusion .—Rizatriptan 10‐mg wafers were equally effective in the treatment of menstrual and nonmenstrual migraine attacks occurring over 6 months, regardless of the precise definition of menstrual association used and even when the outcome criteria were very stringent. These data provide further evidence that triptans are effective treatments for menstrual migraine. To determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks.OBJECTIVETo determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks.Data from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 months were included in a retrospective analysis. Patients used a diary card to record details of each migraine attack and onset of menstruation. Attacks in women were classified as menstrual or nonmenstrual according to 3 time windows relative to onset of menstruation (day 0): -3 to +3 days (7-day window), -2 to + 2 days (5-day window), and 0 to +1 days (2-day window). The analysis looked at the efficacy of rizatriptan 10 mg by menstrual category of attack for each definition on three measures: pain relief at 2 hours (reduction of pain to mild or none), pain free at 2 hours, 24-hours sustained pain free (pain free at 2 hours with no headache recurrence and no use of additional medications from 2 to 24 hours).METHODSData from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 months were included in a retrospective analysis. Patients used a diary card to record details of each migraine attack and onset of menstruation. Attacks in women were classified as menstrual or nonmenstrual according to 3 time windows relative to onset of menstruation (day 0): -3 to +3 days (7-day window), -2 to + 2 days (5-day window), and 0 to +1 days (2-day window). The analysis looked at the efficacy of rizatriptan 10 mg by menstrual category of attack for each definition on three measures: pain relief at 2 hours (reduction of pain to mild or none), pain free at 2 hours, 24-hours sustained pain free (pain free at 2 hours with no headache recurrence and no use of additional medications from 2 to 24 hours).Ninety-five women used rizatriptan 10 mg to treat a total of 1,839 attacks. The percentage of menstrual attacks was 30% for the -3 to +3 days definition, 23% for the -2 to +2 days definition, and 11% for the 0 to +1 days definition. Rizatriptan 10 mg was equally effective in menstrual and nonmenstrual migraine attacks regardless of the definition used. For example, using the -3 to +3 days definition, 78% of menstrual migraine attacks were relieved at 2 hours after dosing compared with 78% of nonmenstrual attacks. Pain relief rates for the other definitions were as follows: -2 to +2 days, menstrual = 78%, nonmenstrual = 78%; 0 to +1 days, menstrual = 79%, and nonmenstrual = 78%. No differences between menstrual and nonmenstrual attacks were found for the 2-hour pain free and 24-hour sustained pain free measures for any of the three definitions.RESULTSNinety-five women used rizatriptan 10 mg to treat a total of 1,839 attacks. The percentage of menstrual attacks was 30% for the -3 to +3 days definition, 23% for the -2 to +2 days definition, and 11% for the 0 to +1 days definition. Rizatriptan 10 mg was equally effective in menstrual and nonmenstrual migraine attacks regardless of the definition used. For example, using the -3 to +3 days definition, 78% of menstrual migraine attacks were relieved at 2 hours after dosing compared with 78% of nonmenstrual attacks. Pain relief rates for the other definitions were as follows: -2 to +2 days, menstrual = 78%, nonmenstrual = 78%; 0 to +1 days, menstrual = 79%, and nonmenstrual = 78%. No differences between menstrual and nonmenstrual attacks were found for the 2-hour pain free and 24-hour sustained pain free measures for any of the three definitions.Rizatriptan 10-mg wafers were equally effective in the treatment of menstrual and nonmenstrual migraine attacks occurring over 6 months, regardless of the precise definition of menstrual association used and even when the outcome criteria were very stringent. These data provide further evidence that triptans are effective treatments for menstrual migraine.CONCLUSIONSRizatriptan 10-mg wafers were equally effective in the treatment of menstrual and nonmenstrual migraine attacks occurring over 6 months, regardless of the precise definition of menstrual association used and even when the outcome criteria were very stringent. These data provide further evidence that triptans are effective treatments for menstrual migraine. To determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks. Data from an extension study where patients with migraine used rizatriptan 10 mg to treat moderate or severe migraine attacks occurring over periods of up to 6 months were included in a retrospective analysis. Patients used a diary card to record details of each migraine attack and onset of menstruation. Attacks in women were classified as menstrual or nonmenstrual according to 3 time windows relative to onset of menstruation (day 0): -3 to +3 days (7-day window), -2 to + 2 days (5-day window), and 0 to +1 days (2-day window). The analysis looked at the efficacy of rizatriptan 10 mg by menstrual category of attack for each definition on three measures: pain relief at 2 hours (reduction of pain to mild or none), pain free at 2 hours, 24-hours sustained pain free (pain free at 2 hours with no headache recurrence and no use of additional medications from 2 to 24 hours). Ninety-five women used rizatriptan 10 mg to treat a total of 1,839 attacks. The percentage of menstrual attacks was 30% for the -3 to +3 days definition, 23% for the -2 to +2 days definition, and 11% for the 0 to +1 days definition. Rizatriptan 10 mg was equally effective in menstrual and nonmenstrual migraine attacks regardless of the definition used. For example, using the -3 to +3 days definition, 78% of menstrual migraine attacks were relieved at 2 hours after dosing compared with 78% of nonmenstrual attacks. Pain relief rates for the other definitions were as follows: -2 to +2 days, menstrual = 78%, nonmenstrual = 78%; 0 to +1 days, menstrual = 79%, and nonmenstrual = 78%. No differences between menstrual and nonmenstrual attacks were found for the 2-hour pain free and 24-hour sustained pain free measures for any of the three definitions. Rizatriptan 10-mg wafers were equally effective in the treatment of menstrual and nonmenstrual migraine attacks occurring over 6 months, regardless of the precise definition of menstrual association used and even when the outcome criteria were very stringent. These data provide further evidence that triptans are effective treatments for menstrual migraine. |
Author | Silberstein, Stephen D. Massiou, Helene Lines, Christopher R. McCarroll, Kathleen A. |
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Keywords | Human Nervous system diseases Agonist Menstruation Prognosis Antimigrainous agent Migraine Oral administration Tryptamine derivatives Cardiovascular disease Serotonine receptor Serotonin agonist Long term Cerebral disorder Vascular disease Chemotherapy Pain Treatment Central nervous system disease Adult Female Rizatriptan Indole derivatives Cerebrovascular disease |
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References | Ahrens SP, Farmer MV, Williams DL, et al. Efficacy and safety of rizatriptan wafer for the acute treatment of migraine. Cephalalgia. 1999;19: 525-530. International Headache Society Clinical Trials Subcommittee. Guidelines for controlled trials of drugs in migraine: second edition. Cephalalgia. 2000;20: 765-786. Johannes CB, Linet MS, Stewart WF, Celentano DD, Lipton RB, Szklo M. Relationship of headache to phase of the menstrual cycle among young women: a daily diary study. Neurology. 1995;45: 1076-1082. Granella F, Sances G, Allais G, et al. Characteristics of menstrual and non-menstrual attacks in women with menstrually related migraine [abstract]. Cephalalgia. 2001;21: 263-264. Silberstein SD, Massiou H, Le Jeunne C, Johnson-Pratt L, McCarroll KA, Lines CR. Rizatriptan in the treatment of menstrual migraine. Obstet Gynecol. 2000;96: 237-242. Granella F, Sances G, Nanferrari C, Costa A, Martignoni E, Manzoni GC. Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. Headache. 1993;33: 385-389. Silberstein SD. The role of sex hormones in headache. Neurology. 1992;42(Suppl 2):37-42. Massiou H, Silberstein SD, McCarroll KA, Allen C, Lines CR. Efficacy of rizatriptan in menstrual migraine: freedom from pain and associated symptoms at 2-h and 24-h sustained pain free status [abstract]. Cephalalgia. 2000;20: 343-344. Loder E, Silberstein SD. Efficacy of zolmitriptan in the acute treatment of menstrually associated migraine [abstract]. Headache. 1999;39: 366. Stewart WF, Lipton RB, Chee E, et al. Menstrual cycle and headache in a population sample of migraineurs. Neurology. 2000;55: 1517-1523. Ferrari MD. Migraine. Lancet. 1998;351: 1043-1051. Loder E. Menstrual migraine. Curr Treatm Opt Neurol. 2001;3: 189-200. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988;8(suppl 7):1-96. Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine in the United States: relation to age, income, race and other sociodemographic factors. JAMA. 1992;287: 64-69. MacGregor EA, Chia H, Vohrah RC, Wilkinson M. Migraine and menstruation: a pilot study. Cephalalgia. 1990;10: 305-310. MacGregor A. Migraine associated with menstruation. Funct Neurol. 2000;15(suppl 1):143-153 Granella F, Sances G, Messa G, De Marenis M, Manzoni GC. Treatment of menstrual migraine. Cephalalgia. 1997;17(suppl 20):35-38. Salonen R, Saiers J. Sumatriptan is effective in the treatment of menstrual migraine: a review of prospective studies and retrospective analyses. Cephalalgia. 1999;19: 16-19. Gross MLP, Barrie M, Bates D, Dowson A, Elrington G. The efficacy of oral sumatriptan in menstrual migraine-a prospective study [abstract]. Cephalalgia. 1995;15(suppl 4):227. 1990; 10 2000; 15 1999; 19 1995; 15 1992; 287 1993; 33 1999; 39 1995; 45 2000; 55 2000; 96 1988; 8 2000; 20 1997; 17 2001; 3 1993 1992; 42 1998; 351 2001; 21 Gross MLP (e_1_2_6_22_2) 1995; 15 Silberstein SD (e_1_2_6_5_2) 1992; 42 Granella F (e_1_2_6_9_2) 2001; 21 Bousser M‐G (e_1_2_6_7_2) 1993 MacGregor A (e_1_2_6_20_2) 2000; 15 e_1_2_6_8_2 Loder E (e_1_2_6_12_2) 1999; 39 e_1_2_6_18_2 e_1_2_6_19_2 e_1_2_6_4_2 e_1_2_6_3_2 e_1_2_6_6_2 e_1_2_6_13_2 Massiou H (e_1_2_6_14_2) 2000; 20 e_1_2_6_2_2 e_1_2_6_10_2 e_1_2_6_11_2 e_1_2_6_21_2 e_1_2_6_16_2 Headache Classification Committee of the International Headache Society (e_1_2_6_17_2) 1988; 8 e_1_2_6_15_2 |
References_xml | – reference: MacGregor EA, Chia H, Vohrah RC, Wilkinson M. Migraine and menstruation: a pilot study. Cephalalgia. 1990;10: 305-310. – reference: Salonen R, Saiers J. Sumatriptan is effective in the treatment of menstrual migraine: a review of prospective studies and retrospective analyses. Cephalalgia. 1999;19: 16-19. – reference: Loder E, Silberstein SD. Efficacy of zolmitriptan in the acute treatment of menstrually associated migraine [abstract]. Headache. 1999;39: 366. – reference: Johannes CB, Linet MS, Stewart WF, Celentano DD, Lipton RB, Szklo M. Relationship of headache to phase of the menstrual cycle among young women: a daily diary study. Neurology. 1995;45: 1076-1082. – reference: Massiou H, Silberstein SD, McCarroll KA, Allen C, Lines CR. Efficacy of rizatriptan in menstrual migraine: freedom from pain and associated symptoms at 2-h and 24-h sustained pain free status [abstract]. Cephalalgia. 2000;20: 343-344. – reference: Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988;8(suppl 7):1-96. – reference: Loder E. Menstrual migraine. Curr Treatm Opt Neurol. 2001;3: 189-200. – reference: Granella F, Sances G, Allais G, et al. Characteristics of menstrual and non-menstrual attacks in women with menstrually related migraine [abstract]. Cephalalgia. 2001;21: 263-264. – reference: MacGregor A. Migraine associated with menstruation. Funct Neurol. 2000;15(suppl 1):143-153 – reference: Stewart WF, Lipton RB, Chee E, et al. Menstrual cycle and headache in a population sample of migraineurs. Neurology. 2000;55: 1517-1523. – reference: Ferrari MD. Migraine. Lancet. 1998;351: 1043-1051. – reference: Ahrens SP, Farmer MV, Williams DL, et al. Efficacy and safety of rizatriptan wafer for the acute treatment of migraine. Cephalalgia. 1999;19: 525-530. – reference: Granella F, Sances G, Messa G, De Marenis M, Manzoni GC. Treatment of menstrual migraine. Cephalalgia. 1997;17(suppl 20):35-38. – reference: Silberstein SD, Massiou H, Le Jeunne C, Johnson-Pratt L, McCarroll KA, Lines CR. Rizatriptan in the treatment of menstrual migraine. Obstet Gynecol. 2000;96: 237-242. – reference: Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine in the United States: relation to age, income, race and other sociodemographic factors. JAMA. 1992;287: 64-69. – reference: Gross MLP, Barrie M, Bates D, Dowson A, Elrington G. The efficacy of oral sumatriptan in menstrual migraine-a prospective study [abstract]. Cephalalgia. 1995;15(suppl 4):227. – reference: Granella F, Sances G, Nanferrari C, Costa A, Martignoni E, Manzoni GC. Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. Headache. 1993;33: 385-389. – reference: International Headache Society Clinical Trials Subcommittee. Guidelines for controlled trials of drugs in migraine: second edition. Cephalalgia. 2000;20: 765-786. – reference: Silberstein SD. The role of sex hormones in headache. Neurology. 1992;42(Suppl 2):37-42. – volume: 8 start-page: 1 issue: suppl 7 year: 1988 end-page: 96 article-title: Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. publication-title: Cephalalgia – volume: 17 start-page: 35 issue: suppl 20 year: 1997 end-page: 38 article-title: Treatment of menstrual migraine. publication-title: Cephalalgia – volume: 19 start-page: 16 year: 1999 end-page: 19 article-title: Sumatriptan is effective in the treatment of menstrual migraine: a review of prospective studies and retrospective analyses. publication-title: Cephalalgia – volume: 3 start-page: 189 year: 2001 end-page: 200 article-title: Menstrual migraine. publication-title: Curr Treatm Opt Neurol – volume: 351 start-page: 1043 year: 1998 end-page: 1051 article-title: Migraine. publication-title: Lancet – volume: 10 start-page: 305 year: 1990 end-page: 310 article-title: Migraine and menstruation: a pilot study. publication-title: Cephalalgia – volume: 15 start-page: 143 issue: suppl 1 year: 2000 end-page: 153 article-title: Migraine associated with menstruation. publication-title: Funct Neurol – volume: 19 start-page: 525 year: 1999 end-page: 530 article-title: Efficacy and safety of rizatriptan wafer for the acute treatment of migraine. publication-title: Cephalalgia – volume: 42 start-page: 37 issue: Suppl 2 year: 1992 end-page: 42 article-title: The role of sex hormones in headache. publication-title: Neurology – volume: 21 start-page: 263 year: 2001 end-page: 264 article-title: Characteristics of menstrual and non‐menstrual attacks in women with menstrually related migraine [abstract]. publication-title: Cephalalgia – volume: 15 start-page: 227 issue: suppl 4 year: 1995 article-title: The efficacy of oral sumatriptan in menstrual migraine—a prospective study [abstract]. publication-title: Cephalalgia – volume: 55 start-page: 1517 year: 2000 end-page: 1523 article-title: Menstrual cycle and headache in a population sample of migraineurs. publication-title: Neurology – volume: 287 start-page: 64 year: 1992 end-page: 69 article-title: Prevalence of migraine in the United States: relation to age, income, race and other sociodemographic factors. publication-title: JAMA – start-page: 413 year: 1993 end-page: 420 – volume: 20 start-page: 343 year: 2000 end-page: 344 article-title: Efficacy of rizatriptan in menstrual migraine: freedom from pain and associated symptoms at 2‐h and 24‐h sustained pain free status [abstract]. publication-title: Cephalalgia – volume: 20 start-page: 765 year: 2000 end-page: 786 article-title: Guidelines for controlled trials of drugs in migraine: second edition. publication-title: Cephalalgia – volume: 45 start-page: 1076 year: 1995 end-page: 1082 article-title: Relationship of headache to phase of the menstrual cycle among young women: a daily diary study. publication-title: Neurology – volume: 39 start-page: 366 year: 1999 article-title: Efficacy of zolmitriptan in the acute treatment of menstrually associated migraine [abstract]. publication-title: Headache – volume: 96 start-page: 237 year: 2000 end-page: 242 article-title: Rizatriptan in the treatment of menstrual migraine. publication-title: Obstet Gynecol – volume: 33 start-page: 385 year: 1993 end-page: 389 article-title: Migraine without aura and reproductive life events: a clinical epidemiological study in 1300 women. publication-title: Headache – volume: 39 start-page: 366 year: 1999 ident: e_1_2_6_12_2 article-title: Efficacy of zolmitriptan in the acute treatment of menstrually associated migraine [abstract]. publication-title: Headache – ident: e_1_2_6_16_2 – start-page: 413 volume-title: The headaches year: 1993 ident: e_1_2_6_7_2 – ident: e_1_2_6_8_2 doi: 10.1177/0333102497017S2011 – volume: 20 start-page: 343 year: 2000 ident: e_1_2_6_14_2 article-title: Efficacy of rizatriptan in menstrual migraine: freedom from pain and associated symptoms at 2‐h and 24‐h sustained pain free status [abstract]. publication-title: Cephalalgia – volume: 15 start-page: 143 issue: 1 year: 2000 ident: e_1_2_6_20_2 article-title: Migraine associated with menstruation. publication-title: Funct Neurol – volume: 42 start-page: 37 issue: 2 year: 1992 ident: e_1_2_6_5_2 article-title: The role of sex hormones in headache. publication-title: Neurology – ident: e_1_2_6_15_2 doi: 10.1046/j.1468-2982.1999.019005525.x – ident: e_1_2_6_19_2 doi: 10.1016/S0140-6736(97)11370-8 – ident: e_1_2_6_3_2 doi: 10.1212/WNL.45.6.1076 – ident: e_1_2_6_18_2 doi: 10.1046/j.1468-2982.2000.00117.x – ident: e_1_2_6_6_2 doi: 10.1046/j.1468-2982.1990.1006305.x – ident: e_1_2_6_2_2 doi: 10.1001/jama.1992.03480010072027 – ident: e_1_2_6_10_2 doi: 10.1212/WNL.55.10.1517 – volume: 8 start-page: 1 issue: 7 year: 1988 ident: e_1_2_6_17_2 article-title: Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. publication-title: Cephalalgia – ident: e_1_2_6_13_2 doi: 10.1016/S0029-7844(00)00880-2 – ident: e_1_2_6_4_2 doi: 10.1111/j.1526-4610.1993.hed3307385.x – ident: e_1_2_6_21_2 doi: 10.1007/s11940-001-0054-1 – volume: 21 start-page: 263 year: 2001 ident: e_1_2_6_9_2 article-title: Characteristics of menstrual and non‐menstrual attacks in women with menstrually related migraine [abstract]. publication-title: Cephalalgia – volume: 15 start-page: 227 issue: 4 year: 1995 ident: e_1_2_6_22_2 article-title: The efficacy of oral sumatriptan in menstrual migraine—a prospective study [abstract]. publication-title: Cephalalgia – ident: e_1_2_6_11_2 doi: 10.1111/j.1468-2982.1999.1901016.x |
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Snippet | Objective.—To determine the long‐term efficacy of oral rizatriptan 10‐mg wafers in the treatment of menstrual migraine attacks.
Methods.—Data from an extension... Objective .—To determine the long‐term efficacy of oral rizatriptan 10‐mg wafers in the treatment of menstrual migraine attacks. Methods .—Data from an... To determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks. Data from an extension study where... Objective.-To determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks. Methods.-Data from an extension... To determine the long-term efficacy of oral rizatriptan 10-mg wafers in the treatment of menstrual migraine attacks.OBJECTIVETo determine the long-term... |
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SubjectTerms | Administration, Oral Adult Biological and medical sciences Cardiovascular system Female Humans Medical sciences menstruation Menstruation - physiology migraine Migraine Disorders - drug therapy Migraine Disorders - physiopathology Pharmacology. Drug treatments Retrospective Studies rizatriptan Serotonin Receptor Agonists - administration & dosage Serotonin Receptor Agonists - therapeutic use Triazoles - administration & dosage Triazoles - therapeutic use Tryptamines Vasodilator agents. Cerebral vasodilators |
Title | Further Evaluation of Rizatriptan in Menstrual Migraine: Retrospective Analysis of Long-term Data |
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