Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways

• Published in: Cellular microbiology Vol. 9; no. 10; pp. 2344 - 2357
• Main Authors: Coers, Jörn, Vance, Russell E, Fontana, Mary F, Dietrich, William F
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.10.2007; Blackwell Publishing Ltd; Hindawi Limited
• Subjects: Animals; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - physiology; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - physiology; Cells, Cultured; Interferon Type I - biosynthesis; Interferon Type I - physiology; Legionella pneumophila - physiology; Luminescent Measurements; Macrophages - metabolism; Macrophages - microbiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Apoptosis-Inhibitory Protein - genetics; Neuronal Apoptosis-Inhibitory Protein - physiology; Signal Transduction; Tumor Necrosis Factor-alpha - biosynthesis; Tumor Necrosis Factor-alpha - physiology

Macrophages from the C57BL/6 (B6) mouse strain restrict intracellular growth of Legionella pneumophila, whereas A/J macrophages are highly permissive. The mechanism by which B6 macrophages restrict Legionella growth remains poorly understood, but is known to require the cytosolic microbe sensors Nai...