Cerebral bioenergetic differences measured by phosphorus‐31 magnetic resonance spectroscopy between bipolar disorder and healthy subjects living in two different regions suggesting possible effects of altitude

• Published in: Psychiatry and clinical neurosciences Vol. 73; no. 9; pp. 581 - 589
• Main Authors: Hwang, Jaeuk, DeLisi, Lynn E., Öngür, Dost, Riley, Colin, Zuo, Chun, Shi, Xianfeng, Sung, Young‐Hoon, Kondo, Douglas, Kim, Tae‐Suk, Villafuerte, Rosemond, Smedberg, Diane, Yurgelun‐Todd, Deborah, Renshaw, Perry F.
• Format: Journal Article
• Language: English
• Published: Melbourne John Wiley & Sons Australia, Ltd 01.09.2019; Wiley Subscription Services, Inc
• Subjects: Adenosine Triphosphate - metabolism; Adult; Aged; Altitude; Bioenergetics; Bipolar disorder; Bipolar Disorder - diagnostic imaging; Bipolar Disorder - metabolism; Boston; Brain - diagnostic imaging; Brain - metabolism; Case-Control Studies; Cortex (cingulate); Energy Metabolism; Female; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - metabolism; high‐energy phosphate; Humans; Hydrogen-Ion Concentration; Hypoxia; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondria; Occipital lobe; Occipital Lobe - diagnostic imaging; Occipital Lobe - metabolism; Oxidative stress; Parietal Lobe - diagnostic imaging; Parietal Lobe - metabolism; pH effects; Phosphates - metabolism; Phosphocreatine; Phosphocreatine - metabolism; Phosphorus; Phosphorus Isotopes; Prefrontal cortex; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - metabolism; Regular; Sea level; Spectrum analysis; Substantia alba; Utah; Veterans; White Matter - diagnostic imaging; White Matter - metabolism; Utah; Boston; altitude; magnetic resonance spectroscopy; bipolar disorder; phosphocreatine; high-energy phosphate

Aim Increased oxidative stress in cerebral mitochondria may follow exposure to the systemic hypobaric hypoxia associated with residing at higher altitudes. Because mitochondrial dysfunction is implicated in bipolar disorder (BD) pathophysiology, this may impact the cerebral bioenergetics in BD. In t...