miR‐3184‐3p enriched in cerebrospinal fluid exosomes contributes to progression of glioma and promotes M2‐like macrophage polarization

Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this stu...

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Published inCancer science Vol. 113; no. 8; pp. 2668 - 2680
Main Authors Xu, Hao, Li, Ming, Pan, Ziwen, Zhang, Zongpu, Gao, Zijie, Zhao, Rongrong, Li, Boyan, Qi, Yanhua, Qiu, Wei, Guo, Qindong, Zhang, Shouji, Fan, Yang, Zhao, Shulin, Wang, Shaobo, Guo, Xing, Deng, Lin, Xue, Hao, Li, Gang
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.08.2022
John Wiley and Sons Inc
Subjects
Apoptosis
Biopsy
Brain cancer
Cell culture
Cerebrospinal fluid
Diagnosis
Exosomes
Flow cytometry
Gene expression
Genotype & phenotype
Glioma
gliomas
Growth factors
Laboratory animals
Leukocyte migration
macrophage
Macrophages
MicroRNAs
miRNA
Original
ORIGINAL ARTICLES
Phenotypes
Proteins
Software
tumor immune microenvironment
Tumors
microRNAs
macrophage
gliomas
tumor immune microenvironment
exosomes
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Abstract Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this study, we found that miR‐3184‐3p was enriched in CSF exosomes in glioma patients and was downregulated after tumour resection. We found that miR‐3184 facilitates glioma progression in two ways. On the one hand, miR‐3184 directly promotes proliferation, migration, and invasion while inhibiting apoptosis in glioma. On the other hand, miR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype, which further aggravates tumour progression. Overall, the current findings uncovered a new mechanism and highlighted the significant role of miR‐3184 in glioma progression. Furthermore, exosomal miR‐3184 could be a considerable factor with potential applications in glioma diagnosis and treatment in the future. MiR‐3184‐3p was enriched in cerebrospinal fluid exosomes in glioma patients. MiR‐3184 promotes proliferation, migration, and invasion in glioma. MiR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype.
AbstractList Abstract Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this study, we found that miR‐3184‐3p was enriched in CSF exosomes in glioma patients and was downregulated after tumour resection. We found that miR‐3184 facilitates glioma progression in two ways. On the one hand, miR‐3184 directly promotes proliferation, migration, and invasion while inhibiting apoptosis in glioma. On the other hand, miR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype, which further aggravates tumour progression. Overall, the current findings uncovered a new mechanism and highlighted the significant role of miR‐3184 in glioma progression. Furthermore, exosomal miR‐3184 could be a considerable factor with potential applications in glioma diagnosis and treatment in the future.
Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this study, we found that miR‐3184‐3p was enriched in CSF exosomes in glioma patients and was downregulated after tumour resection. We found that miR‐3184 facilitates glioma progression in two ways. On the one hand, miR‐3184 directly promotes proliferation, migration, and invasion while inhibiting apoptosis in glioma. On the other hand, miR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype, which further aggravates tumour progression. Overall, the current findings uncovered a new mechanism and highlighted the significant role of miR‐3184 in glioma progression. Furthermore, exosomal miR‐3184 could be a considerable factor with potential applications in glioma diagnosis and treatment in the future.
Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this study, we found that miR‐3184‐3p was enriched in CSF exosomes in glioma patients and was downregulated after tumour resection. We found that miR‐3184 facilitates glioma progression in two ways. On the one hand, miR‐3184 directly promotes proliferation, migration, and invasion while inhibiting apoptosis in glioma. On the other hand, miR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype, which further aggravates tumour progression. Overall, the current findings uncovered a new mechanism and highlighted the significant role of miR‐3184 in glioma progression. Furthermore, exosomal miR‐3184 could be a considerable factor with potential applications in glioma diagnosis and treatment in the future. MiR‐3184‐3p was enriched in cerebrospinal fluid exosomes in glioma patients. MiR‐3184 promotes proliferation, migration, and invasion in glioma. MiR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype.
Author Xu, Hao
Li, Ming
Wang, Shaobo
Li, Gang
Guo, Xing
Li, Boyan
Qi, Yanhua
Zhang, Zongpu
Guo, Qindong
Zhao, Shulin
Gao, Zijie
Xue, Hao
Deng, Lin
Pan, Ziwen
Zhao, Rongrong
Qiu, Wei
Zhang, Shouji
Fan, Yang
AuthorAffiliation 4 Department of Neurosurgery The Affiliated Taian City Centeral Hospital of Qingdao University Taian China
2 Department of Neurosurgery The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai China
1 Department of Neurosurgery Cheeloo College of Medicine and Institute of Brain and Brain‐Inspired Science Qilu Hospital Shandong University Jinan China
3 Shandong Key Laboratory of Brain Function Remodeling Jinan China
AuthorAffiliation_xml – name: 2 Department of Neurosurgery The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai China
– name: 1 Department of Neurosurgery Cheeloo College of Medicine and Institute of Brain and Brain‐Inspired Science Qilu Hospital Shandong University Jinan China
– name: 3 Shandong Key Laboratory of Brain Function Remodeling Jinan China
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Keywords microRNAs
macrophage
gliomas
tumor immune microenvironment
exosomes
Language English
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2022 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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This work was supported by grants from the National Natural Science Foundation of China (Nos. 81874083, 82072776, 82072775, 81702468, 81802966, 81902540, 81874082, 81472353), the Natural Science Foundation of Shandong Province of China (Nos. ZR2019BH057, ZR2020QH174, ZR2021LSW025), the Jinan Science and Technology Bureau of Shandong Province (2021GXRC029), the Key Clinical Research Project of the Clinical Research Center of Shandong University (2020SDUCRCA011) and the Taishan Pandeng Scholar Program of Shandong Province (No. tspd20210322)
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Snippet Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes...
Abstract Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling...
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StartPage 2668
SubjectTerms Apoptosis
Biopsy
Brain cancer
Cell culture
Cerebrospinal fluid
Diagnosis
Exosomes
Flow cytometry
Gene expression
Genotype & phenotype
Glioma
gliomas
Growth factors
Laboratory animals
Leukocyte migration
macrophage
Macrophages
MicroRNAs
miRNA
Original
ORIGINAL ARTICLES
Phenotypes
Proteins
Software
tumor immune microenvironment
Tumors
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Title miR‐3184‐3p enriched in cerebrospinal fluid exosomes contributes to progression of glioma and promotes M2‐like macrophage polarization
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcas.15372
https://www.ncbi.nlm.nih.gov/pubmed/35411604
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Volume 113
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