BAIAP2L1 accelerates breast cancer progression and chemoresistance by activating AKT signaling through binding with ribosomal protein L3

• Published in: Cancer science Vol. 114; no. 3; pp. 764 - 780
• Main Authors: Deng, Ning, Zhang, Xiupeng, Zhang, Yong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2023; John Wiley and Sons Inc
• Subjects: AKT; AKT protein; BAIAP2L1; Breast cancer; Breast Neoplasms - pathology; Cancer therapies; Cell cycle; Cell growth; Cell Line, Tumor; Cell Proliferation - physiology; Chemoresistance; Chemotherapy; Chromatography; Cyclin D1; Drug Resistance, Neoplasm; Epidermal growth factor; Female; Genes; Homology; Humans; Insulin; Kinases; Laboratory animals; Lymph nodes; Mass spectrometry; Metastases; Original; Peptides; PIK3CA; Plasmids; Protein-tyrosine kinase receptors; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Receptors, G-Protein-Coupled; Ribosomal Protein L3; RPL3; Scientific imaging; Signal transduction; Signal Transduction - physiology; Software; Statistical significance; Triple Negative Breast Neoplasms - metabolism; Tumors; China; breast cancer; chemoresistance; AKT; BAIAP2L1; RPL3; PIK3CA

BAI1‐associated protein 2‐like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate, modulates the insulin network; however, its function in breast cancer has not been explored. Immunohistochemical analysis of 140 breast cancer specimens (77 triple‐negative and 63 nontriple‐negativ...