m6A modification–mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability

• Published in: Cancer science Vol. 113; no. 12; pp. 4135 - 4150
• Main Authors: Fang, Deliang, Ou, Xinde, Sun, Kaiyu, Zhou, Xingyu, Li, Youpei, Shi, Peng, Zhao, Zirui, He, Yulong, Peng, Jianjun, Xu, Jianbo
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2022; John Wiley and Sons Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; ALKBH5; Apoptosis; Cell cycle; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; CIP2A; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Hybridization; Metastases; Metastasis; N6-methyladenosine; Non-coding RNA; Original; Phosphatase; Phosphatidylinositol 3-Kinases - metabolism; Phosphoprotein phosphatase; PI3K/AKT; Protein phosphatase; Proteins; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Stomach Neoplasms - pathology; TP53TG1; Tumor suppressor genes; Tumors; Ubiquitination; ALKBH5; CIP2A; gastric cancer; TP53TG1; PI3K/AKT

Long noncoding RNAs (lncRNAs) are associated with various types of cancer. However, the precise roles of many lncRNAs in tumor progression remain unclear. In this study, we found that the expression of the lncRNA TP53TG1 was downregulated in gastric cancer (GC) and it functioned as a tumor suppresso...