A New Gene Family Including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: Characterization from Yeast to Human and Identification of DSCR1-like 2, a Novel Human Member (DSCR1L2)

• Published in: Genomics (San Diego, Calif.) Vol. 64; no. 3; pp. 252 - 263
• Main Authors: Strippoli, Pierluigi, Lenzi, Luca, Petrini, Massimiliano, Carinci, Paolo, Zannotti, Maria
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.03.2000; Elsevier
• Subjects: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Amino Acid Sequence; Animals; Biological and medical sciences; Blotting, Northern; Caenorhabditis elegans Proteins; Down Syndrome - genetics; DSCR1 gene; DSCR1L2 gene; EST; Exons; Expressed Sequence Tags; Fundamental and applied biological sciences. Psychology; Genes. Genome; Humans; Intracellular Signaling Peptides and Proteins; Mice; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Muscle Proteins - genetics; Proteins - genetics; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; ZAKI-4 gene; Chromosomal aberration; Trisomy; Aneuploidy; Homology; Fungi; Conserved sequence; Gene; Multigene family; Ascomycetes; Nematoda; Thallophyta; Human; Splicing; Nucleotide sequence; Chromosome A1; Chromosome G21; Critical region; Tissue specificity; Down syndrome; Protein; Caenorhabditis elegans; Helmintha; Nemathelminthia; Invertebrata; Saccharomyces cerevisiae

A new gene family has been identified on the basis of in-depth bioinformatics analysis of the Down syndrome candidate region 1 (DSCR1) gene, located on 21q22.1. We have determined the complete coding sequences of similar genes in Saccharomyces cerevisiae and Caenorhabditis elegans, as well as that o...