Improving antibody optimization ability of generative adversarial network through large language model

• Published in: Computational and structural biotechnology journal Vol. 21; pp. 5839 - 5850
• Main Authors: Zhao, Wenbin, Luo, Xiaowei, Tong, Fan, Zheng, Xiangwen, Li, Jing, Zhao, Guangyu, Zhao, Dongsheng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2023; Elsevier
• Subjects: Antibody optimization; Generative Adversarial Network; Language model; Antibody optimization; Language model; Generative Adversarial Network

Generative adversarial networks (GANs) have successfully generated functional protein sequences. However, traditional GANs often suffer from inherent randomness, resulting in a lower probability of obtaining desirable sequences. Due to the high cost of wet-lab experiments, the main goal of computer-...