A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 23; pp. 5330 - 5343
• Main Authors: Tateishi, Kensuke, Miyake, Yohei, Kawazu, Masahito, Sasaki, Nobuyoshi, Nakamura, Taishi, Sasame, Jo, Yoshii, Yukie, Ueno, Toshihide, Miyake, Akio, Watanabe, Jun, Matsushita, Yuko, Shiba, Norio, Udaka, Naoko, Ohki, Kentaro, Fink, Alexandria L., Tummala, Shilpa S., Natsumeda, Manabu, Ikegaya, Naoki, Nishi, Mayuko, Ohtake, Makoto, Miyazaki, Ryohei, Suenaga, Jun, Murata, Hidetoshi, Aoki, Ichio, Miller, Julie J., Fujii, Yukihiko, Ryo, Akihide, Yamanaka, Shoji, Mano, Hiroyuki, Cahill, Daniel P., Wakimoto, Hiroaki, Chi, Andrew S., Batchelor, Tracy T., Nagane, Motoo, Ichimura, Koichi, Yamamoto, Tetsuya
• Format: Journal Article
• Language: English
• Published: United States 01.12.2020
• Subjects: Animals; CD79 Antigens - genetics; Central Nervous System Neoplasms - drug therapy; Central Nervous System Neoplasms - metabolism; Central Nervous System Neoplasms - mortality; Central Nervous System Neoplasms - pathology; Female; Glycolysis; Hexokinase - genetics; Hexokinase - metabolism; Humans; Lymphoma - drug therapy; Lymphoma - metabolism; Lymphoma - mortality; Lymphoma - pathology; Mice, SCID; Mutation; Myeloid Differentiation Factor 88 - genetics; NF-kappa B - metabolism; NIMA-Interacting Peptidylprolyl Isomerase - metabolism; Signal Transduction; Transcription Factor RelA - metabolism; Viral Matrix Proteins - genetics; Viral Matrix Proteins - metabolism; Xenograft Model Antitumor Assays

Primary central nervous system lymphoma (PCNSL) is an isolated type of lymphoma of the central nervous system and has a dismal prognosis despite intensive chemotherapy. Recent genomic analyses have identified highly recurrent mutations of MYD88 and CD79B in immunocompetent PCNSL, whereas LMP1 activa...