Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber

• Published in: The American journal of clinical nutrition Vol. 101; no. 2; pp. 251 - 261
• Main Authors: Vitaglione, Paola, Mennella, Ilario, Ferracane, Rosalia, Rivellese, Angela A, Giacco, Rosalba, Ercolini, Danilo, Gibbons, Sean M, La Storia, Antonietta, Gilbert, Jack A, Jonnalagadda, Satya, Thielecke, Frank, Gallo, Maria A, Scalfi, Luca, Fogliano, Vincenzo
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition 01.02.2015; American Society for Clinical Nutrition, Inc
• Subjects: Adult; anthropometric measurements; bacterial communities; Bacteroides; Bifidobacteriales; Biomarkers - blood; blood serum; Body Composition; Body Mass Index; body measurements; Cholesterol - blood; clinical nutrition; Clinical trials; Clostridium; Diet; Dietary fiber; Dietary Fiber - administration & dosage; Edible Grain; Epidemiology; excretion; feces; Feces - chemistry; Feces - microbiology; Feeding Behavior; Female; ferulic acid; Food Quality and Design; fruit consumption; Humans; inflammation; Inflammation - blood; Inflammation - diet therapy; Interleukin-10 - blood; interleukins; Lactobacillus; Life Style; lifestyle; Lifestyles; Male; metabolic diseases; Middle Aged; nutritional intervention; Obesity; Obesity - diet therapy; overweight; Overweight - diet therapy; Plasminogen Activator Inhibitor 1 - blood; Plasminogen Activator Inhibitor 1 - genetics; plasminogen activator inhibitors; Polyphenols; Polyphenols - administration & dosage; Polyphenols - blood; Polyphenols - urine; randomized clinical trials; Triglycerides - blood; Triticum; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - blood; urine; vegetables; VLAG; Wheat; whole grain foods; Young Adult; ferulic acid; wholegrain wheat; bioavailability; inflammation; obesity

Background: Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. Objective: The objective was to assess circulating concentration, excretion, and the physiologic r...