Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber
Background: Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. Objective: The objective was to assess circulating concentration, excretion, and the physiologic r...
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| Published in | The American journal of clinical nutrition Vol. 101; no. 2; pp. 251 - 261 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for Clinical Nutrition
01.02.2015
American Society for Clinical Nutrition, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background: Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. Objective: The objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors. Design: A placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed. Results: WG consumption for 4–8 wk determined a 4-fold increase in serum dihydroferulic acid (DHFA) and a 2-fold increase in fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction in plasma tumor necrosis factor-α (TNF-α) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium . TNF-α reduction correlated with increased Bacteroides and Lactobacillus . No effect of dietary interventions on anthropometric measurements and body composition was found. Conclusions: WG wheat consumption significantly increased excreted FA and circulating DHFA. Bacterial communities influenced fecal FA and were modified by WG wheat consumption. This trial was registered at clinicaltrials.gov as NCT01293175. |
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| AbstractList | Background: Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. Objective: The objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors. Design: A placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed. Results: WG consumption for 4–8 wk determined a 4-fold increase in serum dihydroferulic acid (DHFA) and a 2-fold increase in fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction in plasma tumor necrosis factor-α (TNF-α) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium . TNF-α reduction correlated with increased Bacteroides and Lactobacillus . No effect of dietary interventions on anthropometric measurements and body composition was found. Conclusions: WG wheat consumption significantly increased excreted FA and circulating DHFA. Bacterial communities influenced fecal FA and were modified by WG wheat consumption. This trial was registered at clinicaltrials.gov as NCT01293175. Background: Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. Objective: The objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors. Design: A placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruits and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed. Results: WG consumption for 4–8 wk determined a 4-fold increase of serum dihydroferulic acid (DHFA) and a 2-fold increase of fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction of plasma tumor necrosis factor-a (TNF-a) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium. TNF-a reduction correlated with increased Bacteroides and Lactobacillus. No effect of dietary interventions on anthropometry and body composition was found. Conclusions: WG wheat consumption significantly increased excreted FA and circulating DHFA. Bacterial communities influenced fecal FA and were modified by WG wheat consumption. Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. The objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors. A placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed. WG consumption for 4-8 wk determined a 4-fold increase in serum dihydroferulic acid (DHFA) and a 2-fold increase in fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction in plasma tumor necrosis factor-α (TNF-α) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium. TNF-α reduction correlated with increased Bacteroides and Lactobacillus. No effect of dietary interventions on anthropometric measurements and body composition was found. WG wheat consumption significantly increased excreted FA and circulating DHFA. Bacterial communities influenced fecal FA and were modified by WG wheat consumption. This trial was registered at clinicaltrials.gov as NCT01293175. Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits. The objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors. A placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed. WG consumption for 4-8 wk determined a 4-fold increase in serum dihydroferulic acid (DHFA) and a 2-fold increase in fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction in plasma tumor necrosis factor-a (TNF-a) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium. TNF-a reduction correlated with increased Bacteroides and Lactobacillus. No effect of dietary interventions on anthropometric measurements and body composition was found. WG wheat consumption significantly increased excreted FA and circulating DHFA. Bacterial communities influenced fecal FA and were modified by WG wheat consumption. Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits.BACKGROUNDEpidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in mechanisms underlying health benefits.The objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors.OBJECTIVEThe objective was to assess circulating concentration, excretion, and the physiologic role of WG wheat polyphenols in subjects with suboptimal dietary and lifestyle behaviors.A placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed.DESIGNA placebo-controlled, parallel-group randomized trial with 80 healthy overweight/obese subjects with low intake of fruit and vegetables and sedentary lifestyle was performed. Participants replaced precise portions of refined wheat (RW) with a fixed amount of selected WG wheat or RW products for 8 wk. At baseline and every 4 wk, blood, urine, feces, and anthropometric and body composition measures were collected. Profiles of phenolic acids in biological samples, plasma markers of metabolic disease and inflammation, and fecal microbiota composition were assessed.WG consumption for 4-8 wk determined a 4-fold increase in serum dihydroferulic acid (DHFA) and a 2-fold increase in fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction in plasma tumor necrosis factor-α (TNF-α) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium. TNF-α reduction correlated with increased Bacteroides and Lactobacillus. No effect of dietary interventions on anthropometric measurements and body composition was found.RESULTSWG consumption for 4-8 wk determined a 4-fold increase in serum dihydroferulic acid (DHFA) and a 2-fold increase in fecal ferulic acid (FA) compared with RW consumption (no changes). Similarly, urinary FA at 8 wk doubled the baseline concentration only in WG subjects. Concomitant reduction in plasma tumor necrosis factor-α (TNF-α) after 8 wk and increased interleukin (IL)-10 only after 4 wk with WG compared with RW (P = 0.04) were observed. No significant change in plasma metabolic disease markers over the study period was observed, but a trend toward lower plasma plasminogen activator inhibitor 1 with higher excretion of FA and DHFA in the WG group was found. Fecal FA was associated with baseline low Bifidobacteriales and Bacteroidetes abundances, whereas after WG consumption, it correlated with increased Bacteroidetes and Firmicutes but reduced Clostridium. TNF-α reduction correlated with increased Bacteroides and Lactobacillus. No effect of dietary interventions on anthropometric measurements and body composition was found.WG wheat consumption significantly increased excreted FA and circulating DHFA. Bacterial communities influenced fecal FA and were modified by WG wheat consumption. This trial was registered at clinicaltrials.gov as NCT01293175.CONCLUSIONSWG wheat consumption significantly increased excreted FA and circulating DHFA. Bacterial communities influenced fecal FA and were modified by WG wheat consumption. This trial was registered at clinicaltrials.gov as NCT01293175. |
| Author | Thielecke, Frank Fogliano, Vincenzo Scalfi, Luca Ferracane, Rosalia La Storia, Antonietta Ercolini, Danilo Rivellese, Angela A Mennella, Ilario Gilbert, Jack A Vitaglione, Paola Jonnalagadda, Satya Giacco, Rosalba Gallo, Maria A Gibbons, Sean M |
| Author_xml | – sequence: 1 fullname: Vitaglione, Paola – sequence: 2 fullname: Mennella, Ilario – sequence: 3 fullname: Ferracane, Rosalia – sequence: 4 fullname: Rivellese, Angela A – sequence: 5 fullname: Giacco, Rosalba – sequence: 6 fullname: Ercolini, Danilo – sequence: 7 fullname: Gibbons, Sean M – sequence: 8 fullname: La Storia, Antonietta – sequence: 9 fullname: Gilbert, Jack A – sequence: 10 fullname: Jonnalagadda, Satya – sequence: 11 fullname: Thielecke, Frank – sequence: 12 fullname: Gallo, Maria A – sequence: 13 fullname: Scalfi, Luca – sequence: 14 fullname: Fogliano, Vincenzo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25646321$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1002/biof.1077 10.3945/ajcn.113.067629 10.1007/s00216-013-7288-0 10.2337/diabetes.51.4.1131 10.1111/j.1753-4887.2012.00487.x 10.1017/S0007114510002084 10.1016/j.ijfoodmicro.2007.11.007 10.1124/dmd.109.028019 10.1093/ajcn/87.1.79 10.1371/journal.pone.0085611 10.1046/j.1365-2672.2001.01316.x 10.2174/15701611113116660171 10.1021/jf030404l 10.1038/ismej.2011.139 10.1038/ejcn.2013.207 10.4161/gmic.24707 10.1126/science.1208344 10.3945/jn.110.132944 10.1038/ismej.2012.104 10.1021/jf048456d 10.1002/mnfr.200900580 10.1016/j.numecd.2009.03.025 10.1161/CIR.0b013e318282ab8f 10.3945/jn.112.172668 10.4161/gmic.19897 10.1017/S0007114511007070 10.1080/13510002.1997.11747129 10.1021/jf049144d 10.1517/13543784.9.8.1829 10.4103/2229-3485.83221 10.1017/S0007114507793923 10.1249/01.MSS.0000078924.61453.FB 10.1021/jf2053959 10.1038/ismej.2012.8 10.1186/1475-2891-12-62 10.1016/j.numecd.2009.05.015 10.1139/w04-136 10.1021/jf051437z 10.1017/S0954422410000041 10.1136/bmjopen-2013-003725 10.1038/nmeth.f.303 10.1038/sj.ejcn.1600975 10.1038/ismej.2010.133 10.1017/S0007114510003946 10.1038/nature11053 10.1080/10408390500511821 10.1017/S0007114512003881 10.1093/jn/137.6.1401 10.3945/ajcn.2010.29417 10.1089/mdr.2012.0244 10.1021/jf991266w 10.3945/ajcn.113.064659 10.1002/mnfr.200900056 10.1094/CFW-58-4-0191 10.1111/j.1574-6941.2007.00314.x 10.3945/jn.109.116640 10.3945/jn.113.179473 10.1016/j.tifs.2008.02.005 10.1021/jf010500r 10.1124/dmd.107.017558 10.1002/hep.26510 10.1073/pnas.1005963107 10.1002/biof.1124 10.1016/j.ijbiomac.2007.07.017 10.1111/j.1365-2958.2010.07473.x 10.1017/S0007114510000644 |
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| References | Walter (10.3945/ajcn.114.088120_bib15) 2013; 4 Piombino (10.3945/ajcn.114.088120_bib27) 2014; 9 Vitaglione (10.3945/ajcn.114.088120_bib16) 2008; 19 Wiseman (10.3945/ajcn.114.088120_bib64) 2000; 9 Garcia-Conesa (10.3945/ajcn.114.088120_bib19) 1997; 3 Vardakou (10.3945/ajcn.114.088120_bib48) 2008; 123 Christensen (10.3945/ajcn.114.088120_bib11) 2013; 67 Cerdá (10.3945/ajcn.114.088120_bib65) 2005; 53 Lappi (10.3945/ajcn.114.088120_bib13) 2013; 143 Wu (10.3945/ajcn.114.088120_bib39) 2011; 334 Brownlee (10.3945/ajcn.114.088120_bib55) 2010; 104 Martínez (10.3945/ajcn.114.088120_bib12) 2013; 7 Craig (10.3945/ajcn.114.088120_bib24) 2003; 35 Lozupone (10.3945/ajcn.114.088120_bib30) 2011; 5 Couteau (10.3945/ajcn.114.088120_bib49) 2001; 90 Adom (10.3945/ajcn.114.088120_bib21) 2005; 53 Vitaglione (10.3945/ajcn.114.088120_bib25) 2013; 109 Yatsunenko (10.3945/ajcn.114.088120_bib40) 2012; 486 Andersson (10.3945/ajcn.114.088120_bib31) 2007; 137 Giacco (10.3945/ajcn.114.088120_bib33) 2010; 20 Dodd (10.3945/ajcn.114.088120_bib52) 2011; 79 Go (10.3945/ajcn.114.088120_bib36) 2013; 127 Kostapanos (10.3945/ajcn.114.088120_bib59) 2013; 11 Verrijken (10.3945/ajcn.114.088120_bib60) 2014; 59 Sun (10.3945/ajcn.114.088120_bib20) 2001; 49 Cho (10.3945/ajcn.114.088120_bib3) 2013; 98 Belobrajdic (10.3945/ajcn.114.088120_bib8) 2013; 12 McDonald (10.3945/ajcn.114.088120_bib29) 2012; 6 Lillioja (10.3945/ajcn.114.088120_bib57) 2013; 39 Arranz (10.3945/ajcn.114.088120_bib35) 2010; 54 Fardet (10.3945/ajcn.114.088120_bib7) 2010; 23 Del Rio (10.3945/ajcn.114.088120_bib37) 2010; 20 Stalmach (10.3945/ajcn.114.088120_bib43) 2009; 37 Jonnalagadda (10.3945/ajcn.114.088120_bib2) 2011; 141 Andreasen (10.3945/ajcn.114.088120_bib18) 2000; 48 Renouf (10.3945/ajcn.114.088120_bib44) 2010; 54 Katcher (10.3945/ajcn.114.088120_bib32) 2008; 87 Lefevre (10.3945/ajcn.114.088120_bib4) 2012; 70 Adom (10.3945/ajcn.114.088120_bib17) 2003; 51 Caporaso (10.3945/ajcn.114.088120_bib28) 2010; 7 Ye (10.3945/ajcn.114.088120_bib5) 2012; 142 Vardakou (10.3945/ajcn.114.088120_bib47) 2007; 41 Turpeinen (10.3945/ajcn.114.088120_bib63) 2000; 54 Iacoviello (10.3945/ajcn.114.088120_bib61) 2013; 3 Caporaso (10.3945/ajcn.114.088120_bib26) 2012; 6 Tighe (10.3945/ajcn.114.088120_bib56) 2010; 92 Pol (10.3945/ajcn.114.088120_bib6) 2013; 98 Hayashi (10.3945/ajcn.114.088120_bib50) 2005; 51 Chassard (10.3945/ajcn.114.088120_bib51) 2007; 61 Price (10.3945/ajcn.114.088120_bib34) 2012; 108 Lang (10.3945/ajcn.114.088120_bib45) 2013; 405 Carvalho-Wells (10.3945/ajcn.114.088120_bib10) 2010; 104 Festa (10.3945/ajcn.114.088120_bib58) 2002; 51 Williamson (10.3945/ajcn.114.088120_bib41) 2010; 104 Poquet (10.3945/ajcn.114.088120_bib42) 2008; 36 Slavin (10.3945/ajcn.114.088120_bib1) 2013; 58 Tuohy (10.3945/ajcn.114.088120_bib14) 2012; 60 De Filippo (10.3945/ajcn.114.088120_bib38) 2010; 107 Borges (10.3945/ajcn.114.088120_bib54) 2013; 19 Flint (10.3945/ajcn.114.088120_bib53) 2012; 3 Klepacka (10.3945/ajcn.114.088120_bib23) 2006; 46 Mattila (10.3945/ajcn.114.088120_bib22) 2005; 53 Masters (10.3945/ajcn.114.088120_bib62) 2010; 140 Ludwig (10.3945/ajcn.114.088120_bib46) 2013; 39 Gupta (10.3945/ajcn.114.088120_bib66) 2011; 2 Costabile (10.3945/ajcn.114.088120_bib9) 2008; 99 |
| References_xml | – volume: 39 start-page: 242 year: 2013 ident: 10.3945/ajcn.114.088120_bib57 article-title: Whole grains, type 2 diabetes, coronary heart disease, and hypertension: links to the aleurone preferred over indigestible fiber publication-title: Biofactors doi: 10.1002/biof.1077 – volume: 98 start-page: 594 year: 2013 ident: 10.3945/ajcn.114.088120_bib3 article-title: Consumption of cereal fiber, mixtures of whole grains and bran, and whole grains and risk reduction in type 2 diabetes, obesity, and cardiovascular disease publication-title: Am J Clin Nutr doi: 10.3945/ajcn.113.067629 – volume: 405 start-page: 8487 year: 2013 ident: 10.3945/ajcn.114.088120_bib45 article-title: Bioappearance and pharmacokinetics of bioactives upon coffee consumption publication-title: Anal Bioanal Chem doi: 10.1007/s00216-013-7288-0 – volume: 51 start-page: 1131 year: 2002 ident: 10.3945/ajcn.114.088120_bib58 article-title: Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the Insulin Resistance Atherosclerosis Study publication-title: Diabetes doi: 10.2337/diabetes.51.4.1131 – volume: 70 start-page: 387 year: 2012 ident: 10.3945/ajcn.114.088120_bib4 article-title: Effect of whole grains on markers of subclinical inflammation publication-title: Nutr Rev doi: 10.1111/j.1753-4887.2012.00487.x – volume: 104 start-page: 1353 year: 2010 ident: 10.3945/ajcn.114.088120_bib10 article-title: Determination of the in vivo prebiotic potential of a maize-based whole grain breakfast cereal: a human feeding study publication-title: Br J Nutr doi: 10.1017/S0007114510002084 – volume: 123 start-page: 166 year: 2008 ident: 10.3945/ajcn.114.088120_bib48 article-title: Evaluation of the prebiotic properties of wheat arabinoxylan fractions and induction of hydrolase activity in gut microflora publication-title: Int J Food Microbiol doi: 10.1016/j.ijfoodmicro.2007.11.007 – volume: 37 start-page: 1749 year: 2009 ident: 10.3945/ajcn.114.088120_bib43 article-title: Metabolite profiling of methyl, glucuronyl and sulfate conjugates in plasma and urine derived from chlorogenic acids following the ingestion of coffee by humans: identification of biomarkers of coffee consumption publication-title: Drug Metab Dispos doi: 10.1124/dmd.109.028019 – volume: 87 start-page: 79 year: 2008 ident: 10.3945/ajcn.114.088120_bib32 article-title: The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome publication-title: Am J Clin Nutr doi: 10.1093/ajcn/87.1.79 – volume: 9 start-page: e85611 year: 2014 ident: 10.3945/ajcn.114.088120_bib27 article-title: Saliva from obese individuals suppress the release of aroma compounds from wine publication-title: PLoS ONE doi: 10.1371/journal.pone.0085611 – volume: 90 start-page: 873 year: 2001 ident: 10.3945/ajcn.114.088120_bib49 article-title: Isolation and characterization of human colonic bacteria able to hydrolase chlorogenic acid publication-title: J Appl Microbiol doi: 10.1046/j.1365-2672.2001.01316.x – volume: 11 start-page: 880 year: 2013 ident: 10.3945/ajcn.114.088120_bib59 article-title: Hemostatic factors and the metabolic syndrome publication-title: Curr Vasc Pharmacol doi: 10.2174/15701611113116660171 – volume: 51 start-page: 7825 year: 2003 ident: 10.3945/ajcn.114.088120_bib17 article-title: Phytochemical profiles and antioxidant activity of wheat varieties publication-title: J Agric Food Chem doi: 10.1021/jf030404l – volume: 6 start-page: 610 year: 2012 ident: 10.3945/ajcn.114.088120_bib29 article-title: An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archea publication-title: ISME J doi: 10.1038/ismej.2011.139 – volume: 67 start-page: 1316 year: 2013 ident: 10.3945/ajcn.114.088120_bib11 article-title: Bifidogenic effect of whole-grain wheat during a 12-week energy-restricted dietary intervention in postmenopausal women publication-title: Eur J Clin Nutr doi: 10.1038/ejcn.2013.207 – volume: 4 start-page: 340 year: 2013 ident: 10.3945/ajcn.114.088120_bib15 article-title: Holobiont nutrition: considering the role of the gastrointestinal microbiota in the health benefits of whole grains publication-title: Gut Microbes doi: 10.4161/gmic.24707 – volume: 334 start-page: 105 year: 2011 ident: 10.3945/ajcn.114.088120_bib39 article-title: Linking long-term dietary patterns with gut microbial enterotypes publication-title: Science doi: 10.1126/science.1208344 – volume: 141 start-page: 1011S year: 2011 ident: 10.3945/ajcn.114.088120_bib2 article-title: Putting the whole grain puzzle together: health benefits associated with whole grains—summary of American Society for Nutrition 2010 Satellite Symposium publication-title: J Nutr doi: 10.3945/jn.110.132944 – volume: 7 start-page: 269 year: 2013 ident: 10.3945/ajcn.114.088120_bib12 article-title: Gut microbiome composition is linked to whole grain-induced immunological improvements publication-title: ISME J doi: 10.1038/ismej.2012.104 – volume: 53 start-page: 2297 year: 2005 ident: 10.3945/ajcn.114.088120_bib21 article-title: Phytochemicals and antioxidant activity of milled fractions of different wheat varieties publication-title: J Agric Food Chem doi: 10.1021/jf048456d – volume: 54 start-page: 1646 year: 2010 ident: 10.3945/ajcn.114.088120_bib35 article-title: Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: a study on the Spanish diet publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.200900580 – volume: 20 start-page: 186 year: 2010 ident: 10.3945/ajcn.114.088120_bib33 article-title: Effects of the regular consumption of whole meal wheat foods on cardiovascular risk factors in healthy people publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2009.03.025 – volume: 127 start-page: 143 year: 2013 ident: 10.3945/ajcn.114.088120_bib36 article-title: Heart disease and stroke statistics—2013 update: a report from the American Heart Association publication-title: Circulation doi: 10.1161/CIR.0b013e318282ab8f – volume: 143 start-page: 648 year: 2013 ident: 10.3945/ajcn.114.088120_bib13 article-title: Intake of whole-grain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome publication-title: J Nutr doi: 10.3945/jn.112.172668 – volume: 3 start-page: 289 year: 2012 ident: 10.3945/ajcn.114.088120_bib53 article-title: Microbial degradation of complex carbohydrates in the gut publication-title: Gut Microbes doi: 10.4161/gmic.19897 – volume: 108 start-page: 1644 year: 2012 ident: 10.3945/ajcn.114.088120_bib34 article-title: Evaluation of the effect of wheat aleurone-rich foods on markers of antioxidant status, inflammation and endothelial function in apparently healthy men and women publication-title: Br J Nutr doi: 10.1017/S0007114511007070 – volume: 3 start-page: 319 year: 1997 ident: 10.3945/ajcn.114.088120_bib19 article-title: Ferulic acid dehydrodimers from wheat bran: isolation, purification and antioxidant properties of 8-O-4-diferulic acid publication-title: Redox Rep doi: 10.1080/13510002.1997.11747129 – volume: 53 start-page: 227 year: 2005 ident: 10.3945/ajcn.114.088120_bib65 article-title: Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability publication-title: J Agric Food Chem doi: 10.1021/jf049144d – volume: 9 start-page: 1829 year: 2000 ident: 10.3945/ajcn.114.088120_bib64 article-title: The therapeutic potential of phytoestrogens publication-title: Expert Opin Investig Drugs doi: 10.1517/13543784.9.8.1829 – volume: 2 start-page: 109 year: 2011 ident: 10.3945/ajcn.114.088120_bib66 article-title: Intention-to-treat concept: a review publication-title: Perspect Clin Res. doi: 10.4103/2229-3485.83221 – volume: 99 start-page: 110 year: 2008 ident: 10.3945/ajcn.114.088120_bib9 article-title: Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study publication-title: Br J Nutr doi: 10.1017/S0007114507793923 – volume: 35 start-page: 1381 year: 2003 ident: 10.3945/ajcn.114.088120_bib24 article-title: International physical activity questionnaire: 12-country reliability and validity publication-title: Med Sci Sports Exerc doi: 10.1249/01.MSS.0000078924.61453.FB – volume: 60 start-page: 8776 year: 2012 ident: 10.3945/ajcn.114.088120_bib14 article-title: Up-regulating the human intestinal microbiome using whole plant foods, polyphenols, and/or fiber publication-title: J Agric Food Chem doi: 10.1021/jf2053959 – volume: 6 start-page: 1621 year: 2012 ident: 10.3945/ajcn.114.088120_bib26 article-title: Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms publication-title: ISME J doi: 10.1038/ismej.2012.8 – volume: 12 start-page: 62 year: 2013 ident: 10.3945/ajcn.114.088120_bib8 article-title: The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes publication-title: Nutr J doi: 10.1186/1475-2891-12-62 – volume: 20 start-page: 1 year: 2010 ident: 10.3945/ajcn.114.088120_bib37 article-title: Polyphenols and health: what compounds are involved? publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2009.05.015 – volume: 51 start-page: 251 year: 2005 ident: 10.3945/ajcn.114.088120_bib50 article-title: Direct cloning of genes encoding novel xylanases from the human gut publication-title: Can J Microbiol doi: 10.1139/w04-136 – volume: 53 start-page: 8290 year: 2005 ident: 10.3945/ajcn.114.088120_bib22 article-title: Contents of phenolic acids, alkyl- and alkenylresorcinols, and avenanthramides in commercial grain products publication-title: J Agric Food Chem doi: 10.1021/jf051437z – volume: 23 start-page: 65 year: 2010 ident: 10.3945/ajcn.114.088120_bib7 article-title: New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? publication-title: Nutr Res Rev doi: 10.1017/S0954422410000041 – volume: 3 start-page: e003725 year: 2013 ident: 10.3945/ajcn.114.088120_bib61 article-title: Type 1 plasminogen activator inhibitor as a common risk factor for cancer and ischaemic vascular disease: the EPICOR study publication-title: BMJ Open doi: 10.1136/bmjopen-2013-003725 – volume: 7 start-page: 335 year: 2010 ident: 10.3945/ajcn.114.088120_bib28 article-title: QIIME allows analysis of high-throughput community sequencing data publication-title: Nat Methods doi: 10.1038/nmeth.f.303 – volume: 54 start-page: 418 year: 2000 ident: 10.3945/ajcn.114.088120_bib63 article-title: Similar responses in hemostatic factors after consumption of wholemeal rye bread and low-fiber wheat bread publication-title: Eur J Clin Nutr doi: 10.1038/sj.ejcn.1600975 – volume: 5 start-page: 169 year: 2011 ident: 10.3945/ajcn.114.088120_bib30 article-title: UniFrac: an effective distance metric for microbial community comparison publication-title: ISME J doi: 10.1038/ismej.2010.133 – volume: 104 start-page: S48 issue: Suppl 3 year: 2010 ident: 10.3945/ajcn.114.088120_bib41 article-title: Colonic metabolites of berry polyphenols: the missing link to biological activity? publication-title: Br J Nutr doi: 10.1017/S0007114510003946 – volume: 486 start-page: 222 year: 2012 ident: 10.3945/ajcn.114.088120_bib40 article-title: Human gut microbiome viewed across age and geography publication-title: Nature doi: 10.1038/nature11053 – volume: 46 start-page: 639 year: 2006 ident: 10.3945/ajcn.114.088120_bib23 article-title: Ferulic acid and its position among the phenolic compounds of wheat publication-title: Crit Rev Food Sci Nutr doi: 10.1080/10408390500511821 – volume: 109 start-page: 1832 year: 2013 ident: 10.3945/ajcn.114.088120_bib25 article-title: Human bioavailability of flavanols and phenolic acids from cocoa-nut creams enriched with free or microencapsulated cocoa polyphenols publication-title: Br J Nutr doi: 10.1017/S0007114512003881 – volume: 137 start-page: 1401 year: 2007 ident: 10.3945/ajcn.114.088120_bib31 article-title: Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects publication-title: J Nutr doi: 10.1093/jn/137.6.1401 – volume: 92 start-page: 733 year: 2010 ident: 10.3945/ajcn.114.088120_bib56 article-title: Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial publication-title: Am J Clin Nutr doi: 10.3945/ajcn.2010.29417 – volume: 19 start-page: 256 year: 2013 ident: 10.3945/ajcn.114.088120_bib54 article-title: Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria publication-title: Microb Drug Resist doi: 10.1089/mdr.2012.0244 – volume: 48 start-page: 2837 year: 2000 ident: 10.3945/ajcn.114.088120_bib18 article-title: Content of phenolic acids and ferulic acid dehydrodimers in 17 rye (Secale cereale L.) varieties publication-title: J Agric Food Chem doi: 10.1021/jf991266w – volume: 98 start-page: 872 year: 2013 ident: 10.3945/ajcn.114.088120_bib6 article-title: Whole grain and body weight changes in apparently healthy adults: a systematic review and meta-analysis of randomized controlled studies publication-title: Am J Clin Nutr doi: 10.3945/ajcn.113.064659 – volume: 54 start-page: 760 year: 2010 ident: 10.3945/ajcn.114.088120_bib44 article-title: Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: small intestine and colon are key sites for coffee metabolism publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.200900056 – volume: 58 start-page: 191 year: 2013 ident: 10.3945/ajcn.114.088120_bib1 article-title: Whole grains: definition, dietary recommendations, and health benefits publication-title: Cereal Foods World doi: 10.1094/CFW-58-4-0191 – volume: 61 start-page: 121 year: 2007 ident: 10.3945/ajcn.114.088120_bib51 article-title: Characterization of the xylan-degrading microbial community from human faeces publication-title: FEMS Microbiol Ecol doi: 10.1111/j.1574-6941.2007.00314.x – volume: 140 start-page: 587 year: 2010 ident: 10.3945/ajcn.114.088120_bib62 article-title: Whole and refined grain intakes are related to inflammatory protein concentrations in human plasma publication-title: J Nutr doi: 10.3945/jn.109.116640 – volume: 142 start-page: 1304 year: 2012 ident: 10.3945/ajcn.114.088120_bib5 article-title: Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain publication-title: J Nutr doi: 10.3945/jn.113.179473 – volume: 19 start-page: 451 year: 2008 ident: 10.3945/ajcn.114.088120_bib16 article-title: Cereal dietary fibre: a natural functional ingredient to deliver phenolic compounds into the gut publication-title: Trends Food Sci Technol doi: 10.1016/j.tifs.2008.02.005 – volume: 49 start-page: 5122 year: 2001 ident: 10.3945/ajcn.114.088120_bib20 article-title: Quantitative determination of hydroxycinnamic acids in wheat, rice, rye, and barley straws, maize stems, oil palm frond fiber, and fast-growing poplar wood publication-title: J Agric Food Chem doi: 10.1021/jf010500r – volume: 36 start-page: 190 year: 2008 ident: 10.3945/ajcn.114.088120_bib42 article-title: Transport and metabolism of ferulic acid through the colonic epithelium publication-title: Drug Metab Dispos doi: 10.1124/dmd.107.017558 – volume: 59 start-page: 121 year: 2014 ident: 10.3945/ajcn.114.088120_bib60 article-title: Prothrombotic factors in histologically proven nonalcoholic fatty liver disease and nonalcoholic steatohepatitis publication-title: Hepatology doi: 10.1002/hep.26510 – volume: 107 start-page: 14691 year: 2010 ident: 10.3945/ajcn.114.088120_bib38 article-title: Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1005963107 – volume: 39 start-page: 623 year: 2013 ident: 10.3945/ajcn.114.088120_bib46 article-title: Catabolism of coffee chlorogenic acids by human colonic microbiota publication-title: Biofactors doi: 10.1002/biof.1124 – volume: 41 start-page: 584 year: 2007 ident: 10.3945/ajcn.114.088120_bib47 article-title: In vitro three-stage continuous fermentation of wheat arabinoxylan fractions and induction of hydrolase activity by the gut microflora publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2007.07.017 – volume: 79 start-page: 292 year: 2011 ident: 10.3945/ajcn.114.088120_bib52 article-title: Xylan degradation, a metabolic property shared by rumen and human colonic Bacteroidetes publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2010.07473.x – volume: 104 start-page: 125 year: 2010 ident: 10.3945/ajcn.114.088120_bib55 article-title: Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention publication-title: Br J Nutr doi: 10.1017/S0007114510000644 |
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| Snippet | Background: Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role... Epidemiology associates whole-grain (WG) consumption with several health benefits. Mounting evidence suggests that WG wheat polyphenols play a role in... |
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| SubjectTerms | Adult anthropometric measurements bacterial communities Bacteroides Bifidobacteriales Biomarkers - blood blood serum Body Composition Body Mass Index body measurements Cholesterol - blood clinical nutrition Clinical trials Clostridium Diet Dietary fiber Dietary Fiber - administration & dosage Edible Grain Epidemiology excretion feces Feces - chemistry Feces - microbiology Feeding Behavior Female ferulic acid Food Quality and Design fruit consumption Humans inflammation Inflammation - blood Inflammation - diet therapy Interleukin-10 - blood interleukins Lactobacillus Life Style lifestyle Lifestyles Male metabolic diseases Middle Aged nutritional intervention Obesity Obesity - diet therapy overweight Overweight - diet therapy Plasminogen Activator Inhibitor 1 - blood Plasminogen Activator Inhibitor 1 - genetics plasminogen activator inhibitors Polyphenols Polyphenols - administration & dosage Polyphenols - blood Polyphenols - urine randomized clinical trials Triglycerides - blood Triticum tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - blood urine vegetables VLAG Wheat whole grain foods Young Adult |
| Title | Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber |
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