Lighting up metallohelices: from DNA binders to chemotherapy and photodynamic therapy

• Published in: Chemical communications (Cambridge, England) Vol. 56; no. 55; pp. 7537 - 7548
• Main Authors: Li, Xuezhao, Shi, Zhuolin, Wu, Jinguo, Wu, Jinlong, He, Cheng, Hao, Xiaorou, Duan, Chunying
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 14.07.2020
• Subjects: Animals; antibacterial properties; Antibiotics; Anticancer properties; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Apexes; Biological activity; Cell Line, Tumor; chemical reactions; Chemotherapy; Coordination Complexes - chemistry; Coordination Complexes - therapeutic use; Deoxyribonucleic acid; Diagnostic systems; DNA; DNA - chemistry; drug design; Humans; Lighting; luminescence; Luminescent Agents - chemistry; Luminescent Agents - therapeutic use; metal ions; Metals, Heavy - chemistry; motivation; photochemotherapy; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - chemistry; Photosensitizing Agents - therapeutic use; Self-assembly; singlet oxygen; stereochemistry

The design of novel agents that specifically target DNA and interrupt its normal biological processes is an attractive goal in drug design. Among the promising metallodrugs, metal-directed self-assembled metallohelices with defined three-dimensional stereochemical structures display unique structure...