Lighting up metallohelices: from DNA binders to chemotherapy and photodynamic therapy

The design of novel agents that specifically target DNA and interrupt its normal biological processes is an attractive goal in drug design. Among the promising metallodrugs, metal-directed self-assembled metallohelices with defined three-dimensional stereochemical structures display unique structure...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 55; pp. 7537 - 7548
Main Authors Li, Xuezhao, Shi, Zhuolin, Wu, Jinguo, Wu, Jinlong, He, Cheng, Hao, Xiaorou, Duan, Chunying
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 14.07.2020
Subjects
Animals
antibacterial properties
Antibiotics
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Apexes
Biological activity
Cell Line, Tumor
chemical reactions
Chemotherapy
Coordination Complexes - chemistry
Coordination Complexes - therapeutic use
Deoxyribonucleic acid
Diagnostic systems
DNA
DNA - chemistry
drug design
Humans
Lighting
luminescence
Luminescent Agents - chemistry
Luminescent Agents - therapeutic use
metal ions
Metals, Heavy - chemistry
motivation
photochemotherapy
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - therapeutic use
Self-assembly
singlet oxygen
stereochemistry
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Summary:The design of novel agents that specifically target DNA and interrupt its normal biological processes is an attractive goal in drug design. Among the promising metallodrugs, metal-directed self-assembled metallohelices with defined three-dimensional stereochemical structures display unique structure-inherent and unprecedented noncovalent targeting abilities towards DNA, resulting in excellent anticancer or antibiotic activities. A newly burgeoning hotspot is focusing on lighting them up by embedding luminescent metal ions as the vertices. The photoactive metallohelices that combine strong interactions toward DNA targets and efficient 1 O 2 quantum yield may provide new motivation in diagnostic and photodynamic therapy (PDT) areas. This perspective focuses on research progress on metallohelices as DNA binders and chemotherapeutic agents, and highlights recent advances in fabricating luminescent examples for PDT. The relative assembly strategies are also discussed and compared. Finally, perspectives on the future development of the lit-up metallohelices are presented. DNA distortion induced by metallodrugs is one of the main subjects for drug design. In this Feature Article, the developments of DNA-targeted metallohelices for antitumor chemotherapy and photodynamic therapy are presented with future perspectives.
Bibliography:Xuezhao Li received his PhD degree in 2016 from Dalian University of Technology (DUT). Then he worked with Prof. Chunying Duan as a postdoctoral researcher at State Key Laboratory of Fine Chemicals, DUT. He joined DLUT as an Associate Professor from 2020. His research interests focus on iridium complex-based supramolecular chemistry, photocatalysis and cancer therapy.
Chunying Duan completed his PhD in 1992 at Nanjing University. Since 2006, he has worked at the DaLian University of Technology as a professor. His research interests cover aspects of coordination chemistry, supramolecular chemistry, molecular sensors, chiral materials, and enzyme mimics catalysis.
Cheng He received his PhD degree in 2000 from Nanjing University. After postdoctoral studies at Peking University and the Pohang University of Technology, he was awarded the Alexander von Humboldt fellowship and then worked with Prof. Herbert W. Roesky as a postdoctoral researcher at Goettingen University. He has worked at the Dalian University of Technology as a Professor since 2006. His research interest is in supramolecular coordination chemistry.
Jinguo Wu obtained his BS degree from Dalian University of Technology in 2014. Now, he is a PhD candidate under the supervision of Prof. Cheng He in State Key Laboratory of Fine Chemicals, Dalian University of Technology. His research interests focus on the construction of functional Metal-Organic Cages for photocatalysis and recognition.
Zhuolin Shi received her MS degrees from Henan Key Laboratory of Polyoxometalate Chemistry, Henan University. In 2019, she began to pursue her PhD degree under the supervision of Prof. Cheng He at State Key Laboratory of Fine Chemicals, Dalian University of Technology. Her research interests now focus on polyoxometalate-based metal organic cages/frameworks and relevant catalytic properties.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d0cc02194f