Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway
Aim： Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine （TET）, a major pharmacologically-active compound of Chinese herb Stephania tetrandra S Moore on microglial activation. Methods： The microglia pretreated with or without...
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| Published in | Acta pharmacologica Sinica Vol. 29; no. 2; pp. 245 - 251 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Nature Publishing Group UK
01.02.2008
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| Abstract | Aim： Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine （TET）, a major pharmacologically-active compound of Chinese herb Stephania tetrandra S Moore on microglial activation. Methods： The microglia pretreated with or without TET were activated by lipopolysaccharide （LPS） in vitro. Nitric oxide （NO） release, superoxide anion （O2^-） generation, as well as TNF-α and interleukin-6 （IL-6） production by microglia were measured afterwards. Electrophoretic mobility shift assay was performed to determine whether NF-κB activity in microglia was affected by TET treatment. Results： We found that TET inhibited the LPS-induced activation of microglia by decreasing the production of NO and O2^-, consequently affecting the release of TNF-α and IL-6 in LPS-induced microglial activation. Such suppressive effect was accompanied by inhibiting transcription factor NF-κB activation. Conclusion： Our results suggest that TET might modulate LPS-induced microglial activation by inhibiting the NF-κB-mediated release of inflammatory factors. |
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| AbstractList | Aim:Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine (TET), a major pharmacologically-active compound of Chinese herb Stephania tetrandra S Moore on microglial activation. Methods:The microglia pretreated with or without TET were activated by lipopolysaccharide (LPS) in vitro. Nitric oxide (NO) release, superoxide anion (O sub(2) super(-)) generation, as well as TNF- alpha and interleukin-6 (IL-6) production by microglia were measured afterwards. Electrophoretic mobility shift assay was performed to determine whether NF- Kappa B activity in microglia was affected by TET treatment. Results:We found that TET inhibited the LPS-induced activation of microglia by decreasing the production of NO and O sub(2) super(-), consequently affecting the release of TNF- alpha and IL-6 in LPS-induced microglial activation. Such suppressive effect was accompanied by inhibiting transcription factor NF- Kappa B activation. Conclusion:Our results suggest that TET might modulate LPS-induced microglial activation by inhibiting the NF- Kappa B-mediated release of inflammatory factors.Acta Pharmacologica Sinica (2008) 29, 245-251; doi:10.1111/j.1745-7254.2008.00734.x Aim： Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine （TET）, a major pharmacologically-active compound of Chinese herb Stephania tetrandra S Moore on microglial activation. Methods： The microglia pretreated with or without TET were activated by lipopolysaccharide （LPS） in vitro. Nitric oxide （NO） release, superoxide anion （O2^-） generation, as well as TNF-α and interleukin-6 （IL-6） production by microglia were measured afterwards. Electrophoretic mobility shift assay was performed to determine whether NF-κB activity in microglia was affected by TET treatment. Results： We found that TET inhibited the LPS-induced activation of microglia by decreasing the production of NO and O2^-, consequently affecting the release of TNF-α and IL-6 in LPS-induced microglial activation. Such suppressive effect was accompanied by inhibiting transcription factor NF-κB activation. Conclusion： Our results suggest that TET might modulate LPS-induced microglial activation by inhibiting the NF-κB-mediated release of inflammatory factors. Aim: Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine (TET), a major pharmacologically-active compound of Chinese herb Stephania tetrandra S Moore on microglial activation. Methods: The microglia pretreated with or without TET were activated by lipopolysaccharide (LPS) in vitro . Nitric oxide (NO) release, superoxide anion (O 2 - ) generation, as well as TNF-α and interleukin-6 (IL-6) production by microglia were measured afterwards. Electrophoretic mobility shift assay was performed to determine whether NF-κB activity in microglia was affected by TET treatment. Results: We found that TET inhibited the LPS-induced activation of microglia by decreasing the production of NO and O 2 - , consequently affecting the release of TNF-α and IL-6 in LPS-induced microglial activation. Such suppressive effect was accompanied by inhibiting transcription factor NF-κB activation. Conclusion: Our results suggest that TET might modulate LPS-induced microglial activation by inhibiting the NF-κB-mediated release of inflammatory factors. |
| Author | Yang XUE Ying WANG De-chun FENG Bao-guo XIAO Ling-yun XU |
| AuthorAffiliation | Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; Institute of Neurology, Huashan Hospital, Institute of Brain Science and State Key Laboratory of Medical Meurobiology, Fudan University, Shanghai 200040, China |
| Author_xml | – sequence: 1 givenname: Yang surname: Xue fullname: Xue, Yang organization: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine – sequence: 2 givenname: Ying surname: Wang fullname: Wang, Ying organization: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine – sequence: 3 givenname: De-chun surname: Feng fullname: Feng, De-chun organization: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine – sequence: 4 givenname: Bao-guo surname: Xiao fullname: Xiao, Bao-guo organization: Institute of Neurology, Huashan Hospital, Institute of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University – sequence: 5 givenname: Ling-yun surname: Xu fullname: Xu, Ling-yun email: lyxu@sibs.ac.cn organization: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine |
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| Snippet | Aim： Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine （TET）, a major... Aim: Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine (TET), a major... Aim:Microglial activation has been implicated in many neurological diseases. In this study, we examined the effects of tetrandrine (TET), a major... |
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| SubjectTerms | Biomedical and Life Sciences Biomedicine Immunology Internal Medicine Medical Microbiology original-article Pharmacology/Toxicology Vaccine 抑制作用 氧化一氮 神经胶质 过氧化物阴离子 |
| Title | Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway |
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