Non-invasive in vivo imaging of arthritis in a collagen-induced murine model with phosphatidylserine-binding near-infrared (NIR) dye

• Published in: Arthritis research & therapy Vol. 17; no. 1; p. 50
• Main Authors: Chan, Marion M, Gray, Brian D, Pak, Koon Y, Fong, Dunne
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.03.2015; BioMed Central
• Subjects: Animal experimentation; Animals; Apoptosis; Arthritis; Arthritis, Experimental - chemically induced; Arthritis, Experimental - diagnosis; Carboxy-Lyases; Care and treatment; Collagen; Collagen Type II - toxicity; Diagnosis; Diagnostic Imaging - methods; Inflammation; Male; Mice; Mice, Inbred DBA; Phospholipids; Protein binding; Rheumatoid factor; Spectroscopy, Near-Infrared - methods; Surface active agents; Zinc compounds; Iran

Development of non-invasive molecular imaging techniques that are based on cellular changes in inflammation has been of active interest for arthritis diagnosis. This technology will allow real-time detection of tissue damage and facilitate earlier treatment of the disease, thus representing an impro...