Intracellular free radical production by peripheral blood T lymphocytes from patients with systemic sclerosis: role of NADPH oxidase and ERK1/2

• Published in: Arthritis research & therapy Vol. 17; no. 1; p. 68
• Main Authors: Amico, Donatella, Spadoni, Tatiana, Rovinelli, Marina, Serafini, Marta, D’Amico, Giovanna, Campelli, Nadia, Svegliati Baroni, Silvia, Gabrielli, Armando
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.03.2015; BioMed Central
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Antibodies; Care and treatment; Cells, Cultured; Female; Fibroblasts - immunology; Fibroblasts - metabolism; Fibroblasts - pathology; Gene Expression Regulation; Genetic aspects; Humans; Male; Medical equipment and supplies industry; Medical test kit industry; Middle Aged; Mitogen-Activated Protein Kinase 1 - biosynthesis; Mitogen-Activated Protein Kinase 1 - genetics; NADPH Oxidases - biosynthesis; NADPH Oxidases - genetics; Oxidases; Oxidative Stress; Reactive Oxygen Species - metabolism; Real-Time Polymerase Chain Reaction; RNA; RNA - genetics; Scleroderma (Disease); Scleroderma, Systemic - genetics; Scleroderma, Systemic - metabolism; Scleroderma, Systemic - pathology; Systemic scleroderma; T cells; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; T-Lymphocytes - pathology; Viral antibodies; United States

Abnormal oxidative stress has been described in systemic sclerosis (SSc) and previous works from our laboratory demonstrated an increased generation of reactive oxygen species (ROS) by SSc fibroblasts and monocytes. This study investigated the ability of SSc T lymphocytes to produce ROS, the molecul...