Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 66; no. 3; pp. 434 - 444
• Main Authors: Apple, Fred S, Wu, Alan H B, Sandoval, Yader, Sexter, Anne, Love, Sara A, Myers, Gary, Schulz, Karen, Duh, Show-Hong, Christenson, Robert H
• Format: Journal Article
• Language: English
• Published: England American Association for Clinical Chemistry, Inc 01.03.2020; Oxford University Press
• Subjects: African Americans; Assaying; Banks (Finance); Biomarkers; Calcium-binding protein; Data buses; Epidermal growth factor receptors; Ethylenediaminetetraacetic acid; Glycosylated hemoglobin; Heart; Hemoglobin; Laboratories; Medical screening; Men; Normality; Sensitivity; Sex; Statins; Statistical methods; Statistics; Troponin; Women; Womens health; Israel; United States > US
• ISSN: 0009-9147; 1530-8561; 1530-8561
• DOI: 10.1093/clinchem/hvz029

How to select healthy reference subjects in deriving 99th percentiles for cardiac troponin assays still needs to be clarified. To assist with global implementation of high sensitivity (hs)-cardiac troponin (cTn) I and hs-cTnT assays in clinical practice, we determined overall and sex-specific 99th p...