Tissue-specific inflammation and insulin sensitivity in subjects with obesity

• Published in: Diabetes research and clinical practice Vol. 211; p. 111663
• Main Authors: Oussaada, S.M., Kilicarslan, M., de Weijer, B.A., Gilijamse, P.W., Şekercan, A., Virtue, S., Janssen, I.M.C., van de Laar, A., Demirkiran, A., van Wagensveld, B.A., Houdijk, A.P.J., Jongejan, A., Moerland, P.D., Verheij, J., Geijtenbeek, T.B., Bloks, V.W., de Goffau, M.C., Romijn, J.A., Nieuwdorp, M., Vidal-Puig, A., ter Horst, K.W., Serlie, M.J.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.05.2024
• Subjects: Adipose tissue; Adipose Tissue - metabolism; Adult; Bariatric Surgery; Body Mass Index; Cohort Studies; Female; Humans; Inflammation; Inflammation - metabolism; Insulin resistance; Insulin Resistance - physiology; Intra-Abdominal Fat - metabolism; Liver - metabolism; Male; Middle Aged; Obesity; Obesity - complications; Obesity - metabolism; Weight Loss - physiology; Obesity; Insulin resistance; Inflammation; Adipose tissue; Bariatric surgery

Obesity is associated with low-grade inflammation and insulin resistance (IR). The contribution of adipose tissue (AT) and hepatic inflammation to IR remains unclear. We conducted a study across three cohorts to investigate this relationship. The first cohort consists of six women with normal weight...