Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate

• Published in: Journal of human genetics Vol. 58; no. 7; pp. 461 - 466
• Main Authors: Tin, Adrienne, Colantuoni, Elizabeth, Boerwinkle, Eric, Kottgen, Anna, Franceschini, Nora, Astor, Brad C, Coresh, Josef, Kao, Wen Hong Linda
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.07.2013
• Subjects: Biomarkers; Biomarkers - metabolism; Epidermal growth factor receptors; European Continental Ancestry Group - genetics; Genetic Association Studies - methods; Genome-wide association studies; Genomes; Glomerular filtration rate; Glomerular Filtration Rate - genetics; Glomerular Filtration Rate - physiology; Humans; Kidney - metabolism; Kidneys; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Prospective Studies; Quantitative Trait Loci; Statistical analysis; Statistics; Within-subjects design
• ISSN: 1434-5161; 1435-232X; 1435-232X
• DOI: 10.1038/jhg.2013.23

Studies of multiple measures of a quantitative trait can have greater precision and thus statistical power compared with single-measure studies, but this has rarely been studied in the relation to quantitative trait measurement error models in genetic association studies. Using estimated glomerular...