Biodegradation and in vivo biocompatibility of a degradable, polar/hydrophobic/ionic polyurethane for tissue engineering applications

• Published in: Biomaterials Vol. 32; no. 26; pp. 6034 - 6044
• Main Authors: McBane, Joanne E, Sharifpoor, Soroor, Cai, Kuihua, Labow, Rosalind S, Santerre, J. Paul
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2011
• Subjects: Advanced Basic Science; Animals; Biocompatibility; Biocompatible Materials - adverse effects; Biocompatible Materials - metabolism; Biodegradation; Dentistry; Male; Microscopy, Electron, Scanning; Polylactic glycolic acid; Polyurethane; Polyurethanes - adverse effects; Polyurethanes - metabolism; Porosity; Porous scaffold; Rat subcutaneous implant; Rats; Rats, Wistar; Tissue Engineering - methods; Biodegradation; Rat subcutaneous implant; Biocompatibility; Porous scaffold; Polylactic glycolic acid; Polyurethane

Abstract A degradable, polar/hydrophobic/ionic polyurethane (D-PHI) scaffold was optimized in in vitro studies to yield mechanical properties appropriate to replicate vascular graft tissue while eliciting a more wound-healing phenotype macrophage when compared to established materials. The objective...