Predictive Biomarkers for Immunotherapy in Lung Cancer: Perspective From the International Association for the Study of Lung Cancer Pathology Committee

• Published in: Journal of thoracic oncology Vol. 17; no. 12; pp. 1335 - 1354
• Main Authors: Mino-Kenudson, Mari, Schalper, Kurt, Cooper, Wendy, Dacic, Sanja, Hirsch, Fred R., Jain, Deepali, Lopez-Rios, Fernando, Tsao, Ming Sound, Yatabe, Yasushi, Beasley, Mary Beth, Yu, Hui, Sholl, Lynette M., Brambilla, Elizabeth, Chou, Teh-Ying, Connolly, Casey, Wistuba, Ignacio, Kerr, Keith M., Lantuejoul, Sylvie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2022
• Subjects: B7-H1 Antigen; Biomarkers, Tumor - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Humans; Immunotherapy; Lung cancer; Lung Neoplasms - pathology; Neoadjuvant therapy; PD-L1; Predictive biomarkers; TMB; Tumor Microenvironment; PD-L1; TMB; Neoadjuvant therapy; Predictive biomarkers; Immunotherapy; Lung cancer

Immunotherapy including immune checkpoint inhibitors (ICIs) has become the backbone of treatment for most lung cancers with advanced or metastatic disease. In addition, they have increasingly been used for early stage tumors in neoadjuvant and adjuvant settings. Unfortunately, however, only a subset...