Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

• Published in: Acta pharmaceutica Sinica. B Vol. 14; no. 5; pp. 2119 - 2136
• Main Authors: Peng, Li, Jiang, Yanyi, Chen, Hengxing, Wang, Yongqiang, Lan, Qiusheng, Chen, Shuiqin, Huang, Zhanwang, Zhang, Jingyuan, Tian, Duanqing, Qiu, Yuntan, Cai, Diankui, Peng, Jiangyun, Lu, Daning, Yuan, Xiaoqing, Yang, Xianzhu, Yin, Dong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.05.2024
• Subjects: AJUBA; Core transcriptional regulatory circuitry; EHF; Enhancer; Gastroesophageal adenocarcinoma; KRAS pathway; EHF; Enhancer; Coactivator; Core transcriptional regulatory circuitry; Gastroesophageal adenocarcinoma; KRAS pathway; Gastric adenocarcinoma; Transcription factor; AJUBA; Esophageal adenocarcinoma; Lipid nanoparticles

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug development. However, it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors (TFs) except for the nuclear receptor family of TFs. Lit...