Helicobacter pylori eradication and gastric cancer prevention in a pooled analysis of large-scale cohort studies in Japan

• Published in: Scientific reports Vol. 15; no. 1; pp. 21307 - 8
• Main Authors: Ono, Ayami, Tanaka, Shiori, Sawada, Norie, Goto, Atsushi, Tsugane, Shoichiro, Muraki, Isao, Yamagishi, Kazumasa, Sasaki, Yu, Abe, Yasuhiko, Kayama, Takamasa, Ueno, Yoshiyuki, Saito, Eiko, Yamaji, Taiki, Iwasaki, Motoki, Inoue, Manami
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2025; Nature Portfolio
• Subjects: 692/308/174; 692/4028/67/1504/1829; 692/4028/67/2195; 692/4028/67/2322; 692/499; Adult; Aged; Anti-Bacterial Agents - therapeutic use; Antibodies, Bacterial - blood; Atrophic gastritis; Cohort Studies; Eradication; Female; Gastric cancer; Helicobacter Infections - complications; Helicobacter Infections - drug therapy; Helicobacter Infections - epidemiology; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - drug effects; Humanities and Social Sciences; Humans; Japan; Japan - epidemiology; Male; Middle Aged; multidisciplinary; Pepsinogen A - blood; Prospective cohort study; Risk Factors; Science; Science (multidisciplinary); Stomach Neoplasms - epidemiology; Stomach Neoplasms - microbiology; Stomach Neoplasms - prevention & control; Japan; Eradication; Atrophic gastritis; Gastric cancer; Prospective cohort study; Japan; Helicobacter pylori

Helicobacter pylori ( H. pylori) infection is an established cause of gastric cancer. Although H. pylori eradication is suggested to decrease gastric cancer risk, this has not been fully investigated in general populations. This analysis included 48,530 Japanese men and women aged 40–74 years from f...