Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans

• Published in: Cell metabolism Vol. 23; no. 4; pp. 602 - 609
• Main Authors: Lee, Paul, Bova, Ron, Schofield, Lynne, Bryant, Wendy, Dieckmann, William, Slattery, Anthony, Govendir, Matt A., Emmett, Louise, Greenfield, Jerry R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.04.2016
• Subjects: Adipocytes, Brown - metabolism; Adipose Tissue, Brown - physiology; Adult; beige adipose; Cells, Cultured; circadian; Circadian Rhythm; Female; Glucose - metabolism; Glucose Transporter Type 4 - metabolism; GLUT4; Humans; Male; Middle Aged; Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism; Rev-erb; Thermogenesis; UCP1; Uncoupling Protein 1 - metabolism; Young Adult; beige adipose; UCP1; circadian; GLUT4; Rev-erb

High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excu...