Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans
High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excu...
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Published in | Cell metabolism Vol. 23; no. 4; pp. 602 - 609 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
12.04.2016
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Abstract | High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes.
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•Brown fat utilizes glucose as substrate fuel to produce heat in humans•Human brown fat exhibits a thermogenic circadian rhythm•Brown fat circadian rhythm is glucose responsive•Low brown fat abundance is associated with greater glycaemic fluctuations
Lee et al. reveal how glucose utilization by brown fat in humans is coupled with heat production in a circadian manner. Higher brown fat abundance correlates with lesser glycemia variability, suggesting that brown fat may help buffer glucose fluctuations and maintain whole-body glucose homeostasis over time. |
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AbstractList | High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes. High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes. [Display omitted] •Brown fat utilizes glucose as substrate fuel to produce heat in humans•Human brown fat exhibits a thermogenic circadian rhythm•Brown fat circadian rhythm is glucose responsive•Low brown fat abundance is associated with greater glycaemic fluctuations Lee et al. reveal how glucose utilization by brown fat in humans is coupled with heat production in a circadian manner. Higher brown fat abundance correlates with lesser glycemia variability, suggesting that brown fat may help buffer glucose fluctuations and maintain whole-body glucose homeostasis over time. |
Author | Lee, Paul Bryant, Wendy Govendir, Matt A. Schofield, Lynne Dieckmann, William Greenfield, Jerry R. Slattery, Anthony Emmett, Louise Bova, Ron |
Author_xml | – sequence: 1 givenname: Paul surname: Lee fullname: Lee, Paul email: p.lee@garvan.org.au organization: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia – sequence: 2 givenname: Ron surname: Bova fullname: Bova, Ron organization: Department of Surgery, St. Vincent’s Hospital, Sydney, NSW 2010, Australia – sequence: 3 givenname: Lynne surname: Schofield fullname: Schofield, Lynne organization: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia – sequence: 4 givenname: Wendy surname: Bryant fullname: Bryant, Wendy organization: Diabetes Centre, St. Vincent’s Hospital, Sydney, NSW 2010, Australia – sequence: 5 givenname: William surname: Dieckmann fullname: Dieckmann, William organization: Department of Positron Emission Tomography, National Institutes of Health, Bethesda, MD 20892, USA – sequence: 6 givenname: Anthony surname: Slattery fullname: Slattery, Anthony organization: Department of PET and Nuclear Medicine, St. Vincent’s Hospital, Sydney, NSW 2010, Australia – sequence: 7 givenname: Matt A. surname: Govendir fullname: Govendir, Matt A. organization: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia – sequence: 8 givenname: Louise surname: Emmett fullname: Emmett, Louise organization: Department of PET and Nuclear Medicine, St. Vincent’s Hospital, Sydney, NSW 2010, Australia – sequence: 9 givenname: Jerry R. surname: Greenfield fullname: Greenfield, Jerry R. organization: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26972823$$D View this record in MEDLINE/PubMed |
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Snippet | High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The... |
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SubjectTerms | Adipocytes, Brown - metabolism Adipose Tissue, Brown - physiology Adult beige adipose Cells, Cultured circadian Circadian Rhythm Female Glucose - metabolism Glucose Transporter Type 4 - metabolism GLUT4 Humans Male Middle Aged Nuclear Receptor Subfamily 1, Group D, Member 1 - metabolism Rev-erb Thermogenesis UCP1 Uncoupling Protein 1 - metabolism Young Adult |
Title | Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans |
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