Treatment planning for photodynamic therapy of abscess cavities using patient-specific optical properties measured prior to illumination

• Published in: Physics in medicine & biology Vol. 69; no. 5; pp. 55031 - 55042
• Main Authors: Li, Zihao, Hannan, Md Nafiz, Sharma, Ashwani K, Baran, Timothy M
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 28.02.2024
• Subjects: abscess; Abscess - diagnostic imaging; Abscess - drug therapy; clinical trial; Humans; Light; Lighting; methylene blue; Monte Carlo simulation; Photochemotherapy - methods; photodynamic therapy; Photosensitizing Agents - therapeutic use; Retrospective Studies; clinical trial; methylene blue; photodynamic therapy; Monte Carlo simulation; abscess

Photodynamic therapy (PDT) is an effective antimicrobial therapy that we used to treat human abscess cavities in a Phase 1 clinical trial. This trial included pre-PDT measurements of abscess optical properties, which affect light dose (light fluence) at the abscess wall and PDT response. This study...