RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions

• Published in: Cell stem cell Vol. 20; no. 4; pp. 462 - 477.e6
• Main Authors: Li, Huanhuan, Lai, Ping, Jia, Jinping, Song, Yawei, Xia, Qing, Huang, Kaimeng, He, Na, Ping, Wangfang, Chen, Jiayu, Yang, Zhongzhou, Li, Jiao, Yao, Mingze, Dong, Xiaotao, Zhao, Jicheng, Hou, Chunhui, Esteban, Miguel A., Gao, Shaorong, Pei, Duanqing, Hutchins, Andrew P., Yao, Hongjie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.04.2017
• Subjects: 3' Untranslated Regions - genetics; Animals; Base Sequence; Cell Lineage - genetics; Cellular Reprogramming - genetics; DDX5; DEAD-box RNA Helicases - genetics; DEAD-box RNA Helicases - metabolism; Down-Regulation - genetics; F-Box Proteins - genetics; Fibroblasts - cytology; Fibroblasts - metabolism; Gene Expression Regulation, Developmental; Genetic Loci; H2AK119ub1; Histones - metabolism; Humans; Jumonji Domain-Containing Histone Demethylases - genetics; Mice; Mice, Inbred C57BL; microRNA-125b; MicroRNAs - genetics; MicroRNAs - metabolism; Mouse Embryonic Stem Cells - cytology; Mouse Embryonic Stem Cells - metabolism; Octamer Transcription Factor-3 - metabolism; pluripotency; Pluripotent Stem Cells - cytology; Pluripotent Stem Cells - metabolism; Polycomb Repressive Complex 1 - metabolism; polycomb repressor complex 1; Protein Binding; Repressor Proteins - genetics; Repressor Proteins - metabolism; RNA binding protein; RYBP; somatic cell reprogramming; Up-Regulation; polycomb repressor complex 1; microRNA-125b; DDX5; RYBP; RNA binding protein; pluripotency; somatic cell reprogramming; H2AK119ub1

RNA-binding proteins (RBPs), in addition to their functions in cellular homeostasis, play important roles in lineage specification and maintaining cellular identity. Despite their diverse and essential functions, which touch on nearly all aspects of RNA metabolism, the roles of RBPs in somatic cell...