Approaches to the design of catalytic metallodrugs

• Published in: Current opinion in chemical biology Vol. 25; pp. 172 - 183
• Main Authors: Soldevila-Barreda, Joan J, Sadler, Peter J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2015
• Subjects: Animals; Catalysis; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Drug Design; Humans; Oxidation-Reduction

•How can metal catalysts be used for biochemical transformations?•Catalysis by metal complexes can even be achieved in cells.•Catalysis includes CC bond formation, deprotection/functional group modification.•Degradation of biomolecules and redox modulation can also be achieved.•Four classes of catal...