Key Viral Adaptations Preceding the AIDS Pandemic

• Published in: Cell host & microbe Vol. 25; no. 1; pp. 27 - 38
• Main Authors: Sauter, Daniel, Kirchhoff, Frank
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.01.2019
• Subjects: adaptation; AIDS; arms race; evolution; HIV; primate lentiviruses; restriction factors; viral zoonoses; HIV; viral zoonoses; AIDS; adaptation; restriction factors; arms race; evolution; primate lentiviruses

HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes in the repertoire and function of its accessory genes. Understanding these events and the adaptations to new host species provides key insigh...